Abstract
DNA rearrangements involving restriction fragment length polymorphism and variation in copy number were detected in the human genome by blot hybridization with a cloned segment of human DNA initially present in a cluster of Alu repeat sequences. These rearrangements involve both extrachromosomal circular duplex DNAs and integrated sequences, indicating the presence of transposable elements in human cells.
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Calabretta, B., Robberson, D., Barrera-Saldaña, H. et al. Genome instability in a region of human DNA enriched in Alu repeat sequences. Nature 296, 219–225 (1982). https://doi.org/10.1038/296219a0
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DOI: https://doi.org/10.1038/296219a0
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