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Activation of SV40 genome by 72-base pair tandem repeats of Moloney sarcoma virus

Nature volume 295, pages568–572(1982)Cite this article

Abstract

The simian virus 40 (SV40) 72-base pair (bp) tandem-repeated sequences have a crucial role as an activator element in viral gene expression. We replaced the SV40 72-bp repeat with a 72-bp repeat derived from the long terminal repeat (LTR) of cloned Moloney murine sarcoma virus (MSV) DNA. Although there is no detectable sequence homology to SV40, the MSV repeats can substitute functionally for the SV40 repeats and generate a viable virus in monkey kidney cells.

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Affiliations

  1. Laboratory of Molecular Virology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, 20205, USA

    Barbara Levinson, George Khoury, George Vande Woude & Peter Gruss

Authors
  1. Barbara Levinson
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  2. George Khoury
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  3. George Vande Woude
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  4. Peter Gruss
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Levinson, B., Khoury, G., Vande Woude, G. et al. Activation of SV40 genome by 72-base pair tandem repeats of Moloney sarcoma virus. Nature 295, 568–572 (1982). https://doi.org/10.1038/295568a0

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