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Cellular genes analogous to retroviral onc genes are transcribed in human tumour cells

Nature volume 295, pages 116–119 (1982)Cite this article

Abstract

Polyadenylated RNAs of certain human tumour cell lines are shown to contain transcripts related to the cell-derived transforming onc genes of molecularly cloned primate, murine or avian transforming retrovirus genomes. Thus, analogues of retroviral transforming genes are both present and frequently expressed in human neoplastic cells.

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Authors and Affiliations

  1. Laboratory of Cellular and Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, 20205, USA

    Alessandra Eva, Keith C. Robbins, Philip R. Andersen, Alagarsamy Srinivasan, Steven R. Tronick, E. Premkumar Reddy, Nelson W. Ellmore, Angela T. Galen & Stuart A. Aaronson

  2. Laboratory of Molecular Oncology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, 20205, USA

    James A. Lautenberger & Takis S. Papas

  3. Laboratory of Tumor Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, 20205, USA

    Eric H. Westin, Flossie Wong-Staal & Robert C. Gallo

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  1. Alessandra Eva
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  4. Alagarsamy Srinivasan
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Eva, A., Robbins, K., Andersen, P. et al. Cellular genes analogous to retroviral onc genes are transcribed in human tumour cells. Nature 295, 116–119 (1982). https://doi.org/10.1038/295116a0

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