Abstract
There has recently been considerable interest in the variability observed in the rate of transit of mammalian cells through the cell cycle. Much of the discussion has centred around the transition probability model1,2, partly because the kinetics are easily analysed, but largely because it proposes a single event which controls the rate of cell division. To find such an event would be of importance in the study of control of the rate of growth of mammalian cells. Here, we examine several mathematical models for analysing cell cycle kinetic data, and discuss some of the problems of this approach.
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Smith, J., Laurence, D. & Rudland, P. Limitations of cell kinetics in distinguishing cell cycle models. Nature 293, 648–650 (1981). https://doi.org/10.1038/293648a0
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DOI: https://doi.org/10.1038/293648a0
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