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Stimulation of aldosterone production by β-melanotropin

Abstract

Experimental and clinical evidence suggests that a non-ACTH pituitary factor(s) is important in the regulation of aldosterone secretion in certain conditions1,2. Earlier studies have suggested that β-melanotropin (β-MSH) has only weak steroidogenic potency on the adrenal gland in the rat3,4, but recently Challis et al.5 and Rudman et al.6 have reported that α- and β-MSH have a trophic action on fetal adrenal gland. However, little is known about the effect of β-MSH on aldosterone production. We recently reported that β-lipotropin (β-LPH) stimulates aldosterone production in rat capsular cells7. As the amino acid sequence of β-MSH is contained within the β-LPH structure8,9, we have now investigated the aldosterone-stimulating activity of synthetic β-MSH. Our results indicate that β-MSH causes a dose-dependent increase in aldosterone production in rat capsular cells which is blocked by a synthetic β-MSH analogue. The synthetic hormone does not increase corticosterone production in decapsular cells.

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References

  1. Palmore, W. P. & Mulrow, P. J. Science 158, 1482–1484 (1967).

    Article  ADS  CAS  Google Scholar 

  2. McCaa, R. E., Young, D. B., Guyton, A. C. & McCaa, C. S. Circulation Res. Suppl. 34-35, 15 (1974).

  3. Lowry, P. J., McMartin, C. & Peters, J. J. Endocr. 59, 43–55 (1973).

    Article  CAS  Google Scholar 

  4. Sayers, G., Swallow, R. L. & Giordano, N. D. Endocrinology 88, 1063–1068 (1971).

    Article  CAS  Google Scholar 

  5. Challis, J. R. G. & Torosis, J. D. Nature 269, 818–819 (1977).

    Article  ADS  CAS  Google Scholar 

  6. Rudman, D., Hollins, B. M., Lewis, N. C. & Chawla, R. K. J. clin. Invest. 65, 822–828 (1980).

    Article  CAS  Google Scholar 

  7. Matsuoka, H., Mulrow, P. J. & Li, C. H. Science 209, 307–308 (1980).

    Article  ADS  CAS  Google Scholar 

  8. Li, C. H., Barnafi, L., Chretien, M. & Chung, D. Nature 208, 1093–1094 (1965).

    Article  ADS  CAS  Google Scholar 

  9. Li, C. H. & Chung, D. Nature 260, 623–624 (1976).

    Article  ADS  Google Scholar 

  10. Matsuoka, H., Tan, S. Y. & Mulrow, P. J. Prostaglandins 19, 291–298 (1980).

    Article  CAS  Google Scholar 

  11. Tait, J. F., Tait, S. A. S., Gould, R. P. & Mee, H. R. J. Proc. R. Soc. B185, 375–407 (1974).

    ADS  CAS  Google Scholar 

  12. Li, C. H., Yamashiro, D. & Lemaire, S. Biochemistry 14, 953–956 (1975).

    Article  CAS  Google Scholar 

  13. Lemaire, S., Yamashiro, D., Rao, A. J. & Li, C. H. J. med. Chem. 20, 155–158 (1977).

    Article  CAS  Google Scholar 

  14. Yamashiro, D. & Li, C. H. J. Am. chem. Soc. 100, 5174–5179 (1978).

    Article  CAS  Google Scholar 

  15. Page, R. B., Boyd, J. E. & Mulrow, P. J. Endocr. Res. Commun. 1, 53–62 (1974).

    Article  CAS  Google Scholar 

  16. Vinson, G. P., Whitehouse, B. J., Dell, A., Etienne, T. & Morris, H. R. Nature 284, 464–467 (1980).

    Article  ADS  CAS  Google Scholar 

  17. Lohmar, P. & Li, C. H. Endocrinology 82, 898–904 (1968).

    Article  CAS  Google Scholar 

  18. Lis, M., Gilardeau, C. & Chretien, M. Proc. Soc. exp. Biol. Med. 139, 680–683 (1972).

    Article  CAS  Google Scholar 

  19. Bloomfield, G. A., Scott, A. P., Lowry, P. J., Gilkes, J. J. H. & Rees, L. H. Nature 252, 492–493 (1974).

    Article  ADS  CAS  Google Scholar 

  20. Gilkes, J. J. H. et al. J. clin Endocr. Metab. 40, 450–457 (1975).

    Article  CAS  Google Scholar 

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Matsuoka, H., Mulrow, P., Franco-Saenz, R. et al. Stimulation of aldosterone production by β-melanotropin. Nature 291, 155–156 (1981). https://doi.org/10.1038/291155a0

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