Interacting genes in nematode dauer larva formation


The dauer larva of Caenorhabditis elegans is a developmentally arrested stage induced by starvation or overcrowding. Mutant genes controlling the ability to form dauer larvae interact in a way which allows them to be ordered in a pathway. Mutant phenotypes suggest that the pathway corresponds to neural processing of environmental stimuli.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.


  1. 1

    Beadle, G. W. & Ephrussi, B. Genetics 22, 76–86 (1937).

    CAS  PubMed  PubMed Central  Google Scholar 

  2. 2

    Brenner, S. Genetics 77, 71–94 (1974).

    CAS  PubMed  PubMed Central  Google Scholar 

  3. 3

    von Ehrenstein, G. & Schierenberg, E. in Nematodes as Biological Models Vol 1 (ed. Zuckerman, B. M.) 2–71 (Academic, New York, 1980).

    Google Scholar 

  4. 4

    White, J. G., Southgate, E., Thomson, J. N. & Brenner, S. Phil. Trans. R. Soc. B275, 327–348 (1976).

    ADS  Article  Google Scholar 

  5. 5

    Sulston, J. E., Albertson, D. G. & Thomson, J. N. Devl Biol. 78, 542–576 (1980).

    CAS  Article  Google Scholar 

  6. 6

    Bovien, P. Vidensk. Meddr dansk. naturh. Foren. 101, 1–113 (1937).

    Google Scholar 

  7. 7

    Cassada, R. C. & Russell, R. L. Devl Biol. 46, 326–342 (1975).

    CAS  Article  Google Scholar 

  8. 8

    Cassada, R. C. & Russell, R. L. Fedn Proc. 33, 1476 (1974).

    Google Scholar 

  9. 9

    Klass, M. & Hirsh, D. Nature 260, 523–525 (1976).

    ADS  CAS  Article  Google Scholar 

  10. 10

    Evans, A. A. F. & Perry, R. N. in The Organization of Nematodes (ed. Croll, N. A.) 383–424 (Academic, New York, 1976).

    Google Scholar 

  11. 11

    Albert, P. S., Brown, S. & Riddle, D. L. J. comp. Neural, (in the press).

  12. 12

    Swanson, M. M. & Riddle, D. L. Devl Biol. (in the press).

  13. 13

    Riddle, D. L. Stadler Genet. Symp. 9, 101–120 (1977).

    Google Scholar 

  14. 14

    Cassada, R. C. in Developmental Biology: Pattern Formation and Gene Regulation (eds McMahon, D. M. & Fox, C. F.) 539–547 (Benjamin, Menlo Park, 1975).

    Google Scholar 

  15. 15

    Lewis, J. A. & Hodgkin, J. A. J. comp. Neurol. 172, 489–510 (1977).

    CAS  Article  Google Scholar 

  16. 16

    Ward, S. Proc. natn. Acad. Sci. U.S.A. 70, 817–821 (1973).

    ADS  CAS  Article  Google Scholar 

  17. 17

    Ward, S., Thomson, N., White, J. G. & Brenner, S. J. comp. Neurol. 160, 313–338 (1975).

    CAS  Article  Google Scholar 

  18. 18

    Ware, R. W., Clark, D., Grassland, K. & Russell, R. L. J. comp. Neurol. 162, 71–110 (1975).

    Article  Google Scholar 

  19. 19

    Herman, R. K. & Horvitz, H. R. in Nematodes as Biological Models Vol 1 (ed. Zuckerman, B. M.) 228–261 (Academic, New York, 1980).

    Google Scholar 

  20. 20

    Wood, W. B., Edgar, R. S., King, J., Lielausis, I. & Henninger, M. Fedn Proc. 27, 1160–1166 (1968).

    CAS  Google Scholar 

  21. 21

    Herman, R. K., Horvitz, H. R. & Riddle, D. L. Genet. Maps 1, 183–193 (1980).

    Google Scholar 

Download references

Author information



Rights and permissions

Reprints and Permissions

About this article

Cite this article

Riddle, D., Swanson, M. & Albert, P. Interacting genes in nematode dauer larva formation. Nature 290, 668–671 (1981).

Download citation

Further reading


By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing