Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Article
  • Published:

Interacting genes in nematode dauer larva formation

Abstract

The dauer larva of Caenorhabditis elegans is a developmentally arrested stage induced by starvation or overcrowding. Mutant genes controlling the ability to form dauer larvae interact in a way which allows them to be ordered in a pathway. Mutant phenotypes suggest that the pathway corresponds to neural processing of environmental stimuli.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Purchase on Springer Link

Instant access to full article PDF

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Beadle, G. W. & Ephrussi, B. Genetics 22, 76–86 (1937).

    CAS  PubMed  PubMed Central  Google Scholar 

  2. Brenner, S. Genetics 77, 71–94 (1974).

    CAS  PubMed  PubMed Central  Google Scholar 

  3. von Ehrenstein, G. & Schierenberg, E. in Nematodes as Biological Models Vol 1 (ed. Zuckerman, B. M.) 2–71 (Academic, New York, 1980).

    Google Scholar 

  4. White, J. G., Southgate, E., Thomson, J. N. & Brenner, S. Phil. Trans. R. Soc. B275, 327–348 (1976).

    Article  ADS  Google Scholar 

  5. Sulston, J. E., Albertson, D. G. & Thomson, J. N. Devl Biol. 78, 542–576 (1980).

    Article  CAS  Google Scholar 

  6. Bovien, P. Vidensk. Meddr dansk. naturh. Foren. 101, 1–113 (1937).

    Google Scholar 

  7. Cassada, R. C. & Russell, R. L. Devl Biol. 46, 326–342 (1975).

    Article  CAS  Google Scholar 

  8. Cassada, R. C. & Russell, R. L. Fedn Proc. 33, 1476 (1974).

    Google Scholar 

  9. Klass, M. & Hirsh, D. Nature 260, 523–525 (1976).

    Article  ADS  CAS  PubMed  Google Scholar 

  10. Evans, A. A. F. & Perry, R. N. in The Organization of Nematodes (ed. Croll, N. A.) 383–424 (Academic, New York, 1976).

    Google Scholar 

  11. Albert, P. S., Brown, S. & Riddle, D. L. J. comp. Neural, (in the press).

  12. Swanson, M. M. & Riddle, D. L. Devl Biol. (in the press).

  13. Riddle, D. L. Stadler Genet. Symp. 9, 101–120 (1977).

    Google Scholar 

  14. Cassada, R. C. in Developmental Biology: Pattern Formation and Gene Regulation (eds McMahon, D. M. & Fox, C. F.) 539–547 (Benjamin, Menlo Park, 1975).

    Google Scholar 

  15. Lewis, J. A. & Hodgkin, J. A. J. comp. Neurol. 172, 489–510 (1977).

    Article  CAS  PubMed  Google Scholar 

  16. Ward, S. Proc. natn. Acad. Sci. U.S.A. 70, 817–821 (1973).

    Article  ADS  CAS  Google Scholar 

  17. Ward, S., Thomson, N., White, J. G. & Brenner, S. J. comp. Neurol. 160, 313–338 (1975).

    Article  CAS  PubMed  Google Scholar 

  18. Ware, R. W., Clark, D., Grassland, K. & Russell, R. L. J. comp. Neurol. 162, 71–110 (1975).

    Article  Google Scholar 

  19. Herman, R. K. & Horvitz, H. R. in Nematodes as Biological Models Vol 1 (ed. Zuckerman, B. M.) 228–261 (Academic, New York, 1980).

    Google Scholar 

  20. Wood, W. B., Edgar, R. S., King, J., Lielausis, I. & Henninger, M. Fedn Proc. 27, 1160–1166 (1968).

    CAS  Google Scholar 

  21. Herman, R. K., Horvitz, H. R. & Riddle, D. L. Genet. Maps 1, 183–193 (1980).

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Riddle, D., Swanson, M. & Albert, P. Interacting genes in nematode dauer larva formation. Nature 290, 668–671 (1981). https://doi.org/10.1038/290668a0

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1038/290668a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing