Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Monoclonal antibody identifies a new Ia-like (p29,34) polymorphic system linked to the HLA-D/DR region

Abstract

The Ia antigens of the mouse are the basis for the genetic control of the immune response. The HLA-D/DR locus is considered to be the human counterpart of the Ia subregion of the murine major histocompatibility complex1–4. The HLA-D/DR antigens are polymorphic, and eight well defined alleles have been identified using alloantisera5. More recently, ‘supertypic’ antigens (MB and MT) have been defined which identify clusters of HLA-D/DR specificities6–9. Little is known about the molecular basis for the cellular and serological polymorphism of the HLA-D/DR antigens, as alloantisera are usually of very low titre and heteroantisera frequently lack monospecificity. We present here the preparation and characterization of a monoclonal antibody which defines a new polymorphic system of the HLA-D/DR region. This and similar antisera should now begin to provide the reagents with which to correlate molecular structure with the functional repertoire of the human Ia-like antigens.

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Barnstable, C. J., Jones, E. A. & Crumpton, M. J. Br. med. Bull. 34, 241–246 (1978).

    Article  CAS  PubMed  Google Scholar 

  2. Bodmer, J. G. Br. med. Bull. 34, 233–3239 (1978).

    Article  CAS  PubMed  Google Scholar 

  3. Giphart, M. J. et al. Proc. natn. Acad. Sci. U.S.A. 74, 3533–3536 (1977).

    Article  ADS  CAS  Google Scholar 

  4. Allison, J. P. et al. Proc. natn. Acad. Sci. U.S.A. 75, 3953–3956 (1978).

    Article  ADS  CAS  Google Scholar 

  5. Dupont, B., Braun, D. W., Yunis, E. J. & Carpenter, C. B. in Histocompatibility Testing, 1980 (ed. Terasaki, P. I.) (UCLA Press, Los Angeles, in the press).

  6. Duquenoy, R., Marrai, M. & Vieira, J. in Histocompatibility Testing, 1980 (ed. Terasaki, P. I.) (UCLA Press, Los Angeles, in the press).

  7. Park, M. D., Terasaki, P. I., Nakata, S. & Aoki, D. in Histocompatibility Testing, 1980 (ed. Terasaki, P. I.) (UCLA Press, Los Angeles, in the press).

  8. Brodsky, F. M., Parham, P., Barnstable, C. J., Crumpton, M. J. & Bodmer, W. F. Immun. Rev. 47, 3–61 (1979).

    Article  CAS  PubMed  Google Scholar 

  9. Trucco, M. M., Garotta, G., Stocker, J. W. & Ceppellini, R. Immun. Rev. 47, 219–252 (1979).

    Article  CAS  PubMed  Google Scholar 

  10. Kennett, R. H., Denis, K. A., Tung, A. S. & Klinman, N. R. Curr. Topics Microbiol. Immun. 81, 77–91 (1978).

    CAS  Google Scholar 

  11. Köhler, G. & Milstein, C. Nature 256, 495–497 (1975).

    Article  ADS  PubMed  Google Scholar 

  12. Nadler, L. M., Stashenko, P., Hardy, R. & Schlossman, S. F. J. Immun. 125, 570–577 (1980).

    CAS  PubMed  Google Scholar 

  13. Chess, L., MacDermott, R. P. & Schlossman, S. F. J. Immun. 113, 1113–1121 (1974).

    CAS  PubMed  Google Scholar 

  14. Reinherz, E. L. et al. J. exp. Med. 150, 1472–1482 (1979).

    Article  CAS  PubMed  Google Scholar 

  15. Crumpton, M. J. et al. Proc. R. Soc. B202, 159–175 (1978).

    ADS  CAS  Google Scholar 

  16. Humphreys, R. E. et al. J. exp. Med. 144, 98–112 (1976).

    Article  CAS  PubMed  Google Scholar 

  17. Stashenko, P., Nadler, L. M., Hardy, R. & Schlossman, S. F. J. Immun. 125, 1678–1685 (1980).

    CAS  PubMed  Google Scholar 

  18. Morton, N. E. Am. J. hum. Genet. 7, 277–318 (1955).

    CAS  PubMed  PubMed Central  Google Scholar 

  19. Lampson, L. A. & Levy, R. J. Immun. 125, 293–299 (1980).

    CAS  PubMed  Google Scholar 

  20. Uhr, J. W., Capra, J. D., Vitetta, E. S. & Cook, R. G. Science 206, 292–297 (1979).

    Article  ADS  CAS  PubMed  Google Scholar 

  21. Silver, J., Walker, L. E., Reisfield, R. A., Pellegrino, M. A. & Ferrone, S. Molec. Immun. 16, 37–42 (1979).

    Article  CAS  PubMed  Google Scholar 

  22. Goyert, S. M., Hubert, J. J., Curry, R. A. & Silver, J. Hum. Immun. 1, 161–175 (1980).

    Article  CAS  PubMed  Google Scholar 

  23. Pesando, J. M. et al. J. Immun. 124, 2794–2799 (1980).

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Nadler, L., Stashenko, P., Hardy, R. et al. Monoclonal antibody identifies a new Ia-like (p29,34) polymorphic system linked to the HLA-D/DR region. Nature 290, 591–593 (1981). https://doi.org/10.1038/290591a0

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1038/290591a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing