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Activation of a cellular onc gene by promoter insertion in ALV-induced lymphoid leukosis

Nature volume 290, pages 475–480 (1981)Cite this article

Abstract

Analyses of DNA and RNA from avian leukosis virus (ALV)-induced lymphomas have provided strong evidence that, in most tumours, ALV induces neoplastic disease by activating the c-myc gene, the cellular counterpart of the transforming gene of MC29 virus. The data indicate that, as a rare event, the ALV provirus integrates adjacent to the c-myc gene and that transcription, initiating from a viral promoter, causes enhanced expression of c-myc, leading to neoplastic transformation.

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Authors and Affiliations

  1. The Rockefeller University, 1230 York Avenue, New York, 10021, USA

    William S. Hayward & Benjamin G. Neel

  2. The Institute for Cancer Research, Philadelphia, Pennsylvania, 19111, USA

    Susan M. Astrin

Authors
  1. William S. Hayward
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  2. Benjamin G. Neel
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  3. Susan M. Astrin
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Hayward, W., Neel, B. & Astrin, S. Activation of a cellular onc gene by promoter insertion in ALV-induced lymphoid leukosis. Nature 290, 475–480 (1981). https://doi.org/10.1038/290475a0

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