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Sequence and organization of the human mitochondrial genome

Abstract

The complete sequence of the 16,569-base pair human mitochondrial genome is presented. The genes for the 12S and 16S rRNAs, 22 tRNAs, cytochrome c oxidase subunits I, II and III, ATPase subunit 6, cytochrome b and eight other predicted protein coding genes have been located. The sequence shows extreme economy in that the genes have none or only a few noncoding bases between them, and in many cases the termination codons are not coded in the DNA but are created post-transcriptionally by polyadenylation of the mRNAs.

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Anderson, S., Bankier, A., Barrell, B. et al. Sequence and organization of the human mitochondrial genome. Nature 290, 457–465 (1981). https://doi.org/10.1038/290457a0

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