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Structure of the neuraminidase gene in human influenza virus A/PR/8/34

Nature volume 290, pages 213–217 (1981)Cite this article

Abstract

The complete structure of the neuraminidase gene in influenza A/PR/8/34 has been determined by cloning into the bacteriophage M13 and sequencing with dideoxynucleotide chain terminators. The gene is 1,413 nucleotides long, codes for a protein of 454 amino acids and has five potential glycosylation sites. We suggest that the neuraminidase, unlike the influenza haemagglutinin, is oriented with its N-terminus buried in the viral membrane.

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Authors and Affiliations

  1. MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH, UK

    Stan Fields & Greg Winter

  2. Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, OX1 3RE, UK

    George G. Brownlee

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  1. Stan Fields
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  2. Greg Winter
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  3. George G. Brownlee
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Fields, S., Winter, G. & Brownlee, G. Structure of the neuraminidase gene in human influenza virus A/PR/8/34. Nature 290, 213–217 (1981). https://doi.org/10.1038/290213a0

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