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A human quantitative polymorphism related to Xg blood groups

Nature volume 289, pages 404–405 (1981)Cite this article

Abstract

A monoclonal antibody, 12E7, raised against lymphocytes from a patient with a T-cell acute lymphocytic leukaemia reacts strongly with cortical thymocytes and, to a lesser extent, with other human cells1. The antigen defined by 12E7 is not expressed on mouse or hamster cells; this species specificity allowed us to investigate the genetics of the expression of the 12E7 antigen using human–rodent somatic-cell hybrids2. Hybrid cells which contain the human X chromosome as the only human genetic contribution react with 12E7. The X-linkage of the gene, or genes, controlling 12E7 antigen expression and the fact that 12E7 antigen is also expressed on red blood cells led us to investigate the possibility of a relationship with the X-linked Xg blood group system. Although the 12E7 and Xga antigens seem to be different antigenic determinants specified by different loci, we report here a sex-limited effect involving the Xg phenotype on the expression of 12E7 antigen.

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Authors and Affiliations

  1. Imperial Cancer Research Fund, Lincoln's Inn Fields, London, WC2A 3PX, UK

    P. N. Goodfellow

  2. MRC Blood Group Unit, Wolfson House, University College, London, NW1 2HE, UK

    P. Tippett

Authors
  1. P. N. Goodfellow
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  2. P. Tippett
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Goodfellow, P., Tippett, P. A human quantitative polymorphism related to Xg blood groups. Nature 289, 404–405 (1981). https://doi.org/10.1038/289404a0

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