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Nucleotide sequence and formation of the transforming gene of a mouse sarcoma virus

Nature volume 289, pages 258–262 (1981)Cite this article

Abstract

The complete nucleotide sequence of the transforming gene of a mouse sarcoma virus has been determined. It codes for a protein of 374 amino acids. The nucleotide sequence of the junctions between a murine leukaemia virus and cellular sequences leading to the formation of the viral transforming gene have also been elucidated. The viral transforming sequence and its cellular homologue share an uninterrupted stretch of 1,159 nucleotides, with few base substitutions. The predicted amino acid sequence of the mouse sarcoma virus transforming gene was found to share considerable homology with the proposed amino acid sequence of the avian sarcoma virus oncogene (src) product.

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Author notes

  1. Anton J. M. Berns

    Present address: Laboratory of Biochemistry, University of Nijmegen, Nijmegen, The Netherlands

  2. Russell F. Doolittle: Department of Chemistry, University of California, San Diego, La Jolla, California 92093

Authors and Affiliations

  1. Tumor Virology Laboratory, The Salk Institute, PO Box 85800, San Diego, California, 92138

    Charles Van Beveren, Janice A. Galleshaw, Vivian Jonas, Anton J. M. Berns, Russell F. Doolittle, Daniel J. Donoghue & Inder M. Verma

Authors
  1. Charles Van Beveren
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  2. Janice A. Galleshaw
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  3. Vivian Jonas
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  4. Anton J. M. Berns
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  5. Russell F. Doolittle
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  6. Daniel J. Donoghue
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  7. Inder M. Verma
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Van Beveren, C., Galleshaw, J., Jonas, V. et al. Nucleotide sequence and formation of the transforming gene of a mouse sarcoma virus. Nature 289, 258–262 (1981). https://doi.org/10.1038/289258a0

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