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A new class of angiotensin-converting enzyme inhibitors

Abstract

Much current attention focuses on the renin–angiotensin system in relation to mechanisms controlling blood pressure and renal function. Recent demonstrations (ref 1, ref. 2 and refs therein) that angiotensin-converting enzyme inhibitors show promising clinical antihypertensive properties have been of particular interest. We now report on the design of a novel series of substituted N-carboxymethyl-dipeptides which are active in inhibiting angiotensin-converting enzyme at nanomolar levels. We suggest that these compounds are transition-state inhibitors and that extensions of this design to other metalloendopeptidases merit further study.

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Patchett, A., Harris, E., Tristram, E. et al. A new class of angiotensin-converting enzyme inhibitors. Nature 288, 280–283 (1980). https://doi.org/10.1038/288280a0

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