Abstract
We describe here experiments which reveal a new physiological specialization in the endplate (synaptic) region of skeletal muscle fibres. Using a vibrating microelectrode1 which can detect small currents flowing in extracellular fluid, we have found that the membrane in the endplate region behaves as though a steady positive current is generated in this location. Current re-enters the fibre in the extrajunctional region. Further experiments show that this current is dependent on the activity of the sodium pump. The electric field created by this current may be important for long-term interactions between muscle and nerve.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Jaffe, L. F. & Nuccitelli, R. J. Cell Biol. 63, 614–628 (1974).
Bekoff, A. & Betz, W. J. J. physiol., Lond. 271, 25–40 (1977).
Detweiler, D. K. Fedn Proc. 26, 1119–1124 (1967).
Thomas, R. C. Physiol. Rev. 52, 563–594 (1972).
Orida, N. & Poo, M-m. Nature 275, 31–35 (1978).
Jaffe, L. F. & Poo, M.-m. J. exp. Zool. 209, 115–128 (1979).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Betz, W., Caldwell, J., Ribchester, R. et al. Endogenous electric field around muscle fibres depends on the Na+–K+ pump. Nature 287, 235–237 (1980). https://doi.org/10.1038/287235a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/287235a0
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.