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Thyrotropin-releasing hormone—CNS action to stimulate gastric acid secretion

Abstract

Much physiological and pharmacological evidence has accumulated to suggest that the autonomie nervous system has an important role in the peripheral modulation of gastric secretion1, although the neurochemical mediators in the brain which initiate or modulate autonomie input are poorly understood1–4. Recently, the demonstration that some oligopeptides present in mammalian brain act in the central nervous system (CNS) to influence profoundly glucoregulation5, thermoregulation6,7, blood pressure8,9, sympathetic outflow9–11, muscular activity of gut12,13 and stress-induced gastric haemorrhagic lesions14 have led us to examine a possible role for some of these endogenous brain oligopeptides as chemical messengers involved in the CNS modulation of gastric secretion. We report here that thyrotropin-releasing hormone (TRH) acts within the CNS to elicit a vagus-dependent stimulation of gastric acid secretion.

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