Abstract
The central actions of the steroid hormone progesterone remain an enigma. However, there is no doubt that this hormone has a vital role in the control of sexual function and behaviour in many species, including man. Furthermore, progesterone may be involved in the premenstrual and postpartum syndromes1. It would therefore be very useful to know the role and mechanism of action of progesterone in the brain. We now show that there are differences between progesterone receptors in brain and uterus, and possibly in the distribution of the serum progesterone-binding protein, corticosteroid-binding globulin (CBG), which may enter uterine but not brain cells.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Dalton, K. The Premenstrual Syndrome (Heinemann, London, 1974).
King, R. J. B. & Mainwaring, W. I. P. Steroid-Cell Interactions (Butterworths, London, 1974).
Stumpf, W. E. Science 162, 1001–1003, (1968).
Pfaff, D. W. Science 161, 1355–1356 (1968).
Kato, J. & Onouchi, T. Endocr. jap. 20, 429–432 (1973).
McEwen, B. S., de Kloet, R. & Wallach, G. Brain Res. 105, 129–136 (1976).
Ginsburg, M., Greenstein, B. D., MacLusky, N. J., Morris, I. D. & Thomas, P. J. Steroids 23, 773–792 (1974).
Barley, J., Ginsburg, M., Greenstein, B. D., MacLusky, N. J. & Thomas, P. J. Brain Res. 100, 383–393 (1975).
Wade, G. N. & Feder, H. H. Brain Res. 45, 525–543 (1972).
Luttge, W. C., Wallis, C. J. & Hall, N. R. Brain Res. 71, 105–115 (1974).
Sar, M. & Stumpf, W. E. Science 182, 1266–1268 (1973).
Karavolas, H. J., Hodges, D. R., O'Brien, D. J. & McKenzie, K. M. Endocrinology 104, 1418–1425 (1979).
Westphal, U. in Biochemical Actions of Hormones Vol. 1 (ed. Litwack, G.) 209–265 (Academic, New York, 1972).
Greenstein, B. D. J. Endocr. 79, 327–338 (1978).
Lee, H., Davies, I. J. & Ryan, K. J. Endocrinology 104, 791–800 (1979).
Moguilewsky, M. & Raynaud, J.-P. Steroids 30, 99–109, (1977).
Kato, J. & Onouchi, T. Endocrinology 101, 920–928 (197).
MacLusky, N. J. & McEwen, B. S. Nature 274, 276–278 (1978).
Moguilewsky, M. & Raynaud, J.-P. Endocrinology 105, 516–522, (1979).
Blaustein, J. D. & Wade, G. N. Brain Res. 140, 360–367 (1978).
Seiki, K., Haurki, Y., Imanishi, Y. & Enomoto, T. J. Endocr. 82, 347–360 (1979).
Zava, D. T., Landrum, B., Horwitz, K. B. & McGuire, W. L. Endocrinology 104, 1007–1012 (1979).
Nathanielz, P. W. & Abel, M. J. Endocr. 57, 47–54 (1973).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Al-Khouri, H., Greenstein, B. Role of corticosteroid-binding globulin in interaction of corticosterone with uterine and brain progesterone receptors. Nature 287, 58–60 (1980). https://doi.org/10.1038/287058a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/287058a0
This article is cited by
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
