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RNA splicing generates a variant light chain from an aberrantly rearranged κ gene

Nature volume 286, pages 776779 (21 August 1980) | Download Citation

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Abstract

Both Cκ regions in MPC 11 cells are rearranged into active transcription units, one producing a normal κ chain and the other an internally deleted κ fragment lacking a V region. The gene coding for the κ fragment mRNA is aberrantly rearranged and lacks a site for V → Cκ splicing. An alternative splicing event which deletes the V region from the nuclear RNA precursor generates the κ fragment mRNA.

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Author information

Affiliations

  1. Molecular Biology Institute and Department of Microbiology and Immunology, UCLA School of Medicine, Los Angeles, California 90024

    • Edmund Choi
    •  & Randolph Wall
  2. Department of Microbiology, University of Virginia School of Medicine, Charlottesville, Virginia 22908

    • Michael Kuehl

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https://doi.org/10.1038/286776a0

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