Abstract
Both Cκ regions in MPC 11 cells are rearranged into active transcription units, one producing a normal κ chain and the other an internally deleted κ fragment lacking a V region. The gene coding for the κ fragment mRNA is aberrantly rearranged and lacks a site for V → Cκ splicing. An alternative splicing event which deletes the V region from the nuclear RNA precursor generates the κ fragment mRNA.
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Choi, E., Kuehl, M. & Wall, R. RNA splicing generates a variant light chain from an aberrantly rearranged κ gene. Nature 286, 776–779 (1980). https://doi.org/10.1038/286776a0
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DOI: https://doi.org/10.1038/286776a0
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