Letter | Published:

Myosin from fetal hearts contains the skeletal muscle embryonic light chain

Nature volume 286, pages 731733 (14 August 1980) | Download Citation

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Abstract

The contractile proteins of adult skeletal and cardiac muscle tissue are very similar. Some of these proteins are identical in amino acid sequence1,2 or differ only slightly3. Various structural studies have shown that the heavy and light chains of myosin are also homologous in skeletal and cardiac muscles4–11. In developing skeletal muscles, certain myosin subunits are present which are not found in the corresponding adult muscle7,10–13. Whether fetal cardiac muscle also contains myosin subunits homologous to these early forms is not known. We now report that ventricular myosin of fetal rats has a light chain polypeptide corresponding to the skeletal muscle embryonic light chain11. This result provides further evidence that a form of myosin light chain, not detectable in adult skeletal or ventricular myosin, is characteristic of the early stages of striated muscle development14.

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Author information

Affiliations

  1. Département de Biologie Moléculaire, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris, France

    • Robert G. Whalen
    •  & Susan M. Sell

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DOI

https://doi.org/10.1038/286731a0

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