Letter | Published:

Receptors for concanavalin A cluster at the front of polarized neutrophils

Nature volume 286, pages 725727 (14 August 1980) | Download Citation

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Abstract

Polymorphonuclear neutrophils (PMN) can recognize, engulf and kill microorganisms and are thus an important host defence against infection. The initial encounter between a microbe and the neutrophil takes place at the neutrophil surface. Receptors, including those for the Fc end of the immunoglobulin G (ref. 1), the C3b component of complement2, formyl peptides3 and plant lectins4 have been identified on the surface of neutrophils. We have now examined the surface pattern and arrangement of receptors for the plant lectin concanavalin A (Con A) to determine if the surface receptor array varied with the functional state of the neutrophil. We found that receptors for Con A clustered at the front of polarized neutrophils.

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Author information

Affiliations

  1. Department of Medicine, Box 385, University of Virginia School of Medicine, Charlottesville, Virginia 22908

    • D. L. Weinbaum
    • , J. A. Sullivan
    •  & G. L. Mandell

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DOI

https://doi.org/10.1038/286725a0

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