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Asymmetric Fc receptor distribution on human PMN oriented in a chemotactic gradient

Naturevolume 286pages724725 (1980) | Download Citation



Phagocytosis of antibody-coated particles and immune complexes by polymorphonuclear leukocytes (PMN) and macrophages is initiated by binding to Fc receptors1–3 While it appears that subsequent ingestion requires receptor–Fc interactions to occur along the entire periphery of the particle4, the distribution of Fc receptors over the leukocyte surface is unknown. We show here that during chemotaxis the Fc receptors of human neutrophils are localized to the cell's leading edge. This restricted receptor topography coincides with cell orientation and does not require net forward movement of PMN. Thus, Fc receptors are located in precisely that region of the cell most likely to first encounter opsonized particles.

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  1. 1

    Rabinovitch, M. in Mononuclear Phagocytes (ed. van Furth, R.) 299–315 (Blackwell, Philadelphia, 1970).

  2. 2

    Griffin, J. A. & Griffin, F. M. Jr J. exp. Med. 150, 653–675 (1979).

  3. 3

    Huber, H. & Fudenberg, H. H. Ser. Haemat. 3 part 2, 160–175 (1970).

  4. 4

    Griffin, F. M. Jr, Griffin, J., Leider, J. E. & Silverstein, S. C. J. exp. Med. 142, 1263–1282 (1975).

  5. 5

    Walter, R. J., Berlin, R. D., Pfeiffer, J. R. & Oliver, J. M. J. Cell Biol. 86, 199–211 (1980)

  6. 6

    Zigmond, S. H. J. Cell Biol. 75, 606–616 (1977).

  7. 7

    Marasco, W. A., Becker, E. L. & Oliver, J. M. Am. J. Path. 98, 749–768 (1980).

  8. 8

    Oliver, J. M., Krawiec, J. A. & Becker, E. L. J. reticuloend. Soc. 24, 697–704 (1978).

  9. 9

    Bessis, M. & DeBoisfleury, A. Blood Cells 2, 365–410 (1976).

  10. 10

    Ash, J. F., Louvard, D. & Singer, S. J. Proc. natn. Acad. Sci. U.S.A. 74, 5584–5588 (1977).

  11. 11

    Greenspan, H. P. J. theor.Biol. 70, 125–134 (1978).

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  1. Department of Physiology, University of Connecticut Health Center, Farmington, Connecticut, 06032

    • Robert J. Walter
    • , Richard D. Berlin
    •  & Janet M. Oliver


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