Abstract
Phagocytosis of antibody-coated particles and immune complexes by polymorphonuclear leukocytes (PMN) and macrophages is initiated by binding to Fc receptors1–3 While it appears that subsequent ingestion requires receptor–Fc interactions to occur along the entire periphery of the particle4, the distribution of Fc receptors over the leukocyte surface is unknown. We show here that during chemotaxis the Fc receptors of human neutrophils are localized to the cell's leading edge. This restricted receptor topography coincides with cell orientation and does not require net forward movement of PMN. Thus, Fc receptors are located in precisely that region of the cell most likely to first encounter opsonized particles.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Rabinovitch, M. in Mononuclear Phagocytes (ed. van Furth, R.) 299–315 (Blackwell, Philadelphia, 1970).
Griffin, J. A. & Griffin, F. M. Jr J. exp. Med. 150, 653–675 (1979).
Huber, H. & Fudenberg, H. H. Ser. Haemat. 3 part 2, 160–175 (1970).
Griffin, F. M. Jr, Griffin, J., Leider, J. E. & Silverstein, S. C. J. exp. Med. 142, 1263–1282 (1975).
Walter, R. J., Berlin, R. D., Pfeiffer, J. R. & Oliver, J. M. J. Cell Biol. 86, 199–211 (1980)
Zigmond, S. H. J. Cell Biol. 75, 606–616 (1977).
Marasco, W. A., Becker, E. L. & Oliver, J. M. Am. J. Path. 98, 749–768 (1980).
Oliver, J. M., Krawiec, J. A. & Becker, E. L. J. reticuloend. Soc. 24, 697–704 (1978).
Bessis, M. & DeBoisfleury, A. Blood Cells 2, 365–410 (1976).
Ash, J. F., Louvard, D. & Singer, S. J. Proc. natn. Acad. Sci. U.S.A. 74, 5584–5588 (1977).
Greenspan, H. P. J. theor.Biol. 70, 125–134 (1978).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Walter, R., Berlin, R. & Oliver, J. Asymmetric Fc receptor distribution on human PMN oriented in a chemotactic gradient. Nature 286, 724–725 (1980). https://doi.org/10.1038/286724a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/286724a0
This article is cited by
-
Moving proteins
Nature (1989)
-
Effect of fluoride on movement of concanavalin A-acceptor molecules of human neutrophils
Inflammation (1989)
-
Clostridial collagenase
Inflammation (1986)
-
Fc receptor—More answers, more questions
Folia Microbiologica (1984)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.