Letter | Published:

Mechanism of origin of complete hydatidiform moles

Nature volume 286, pages 714716 (14 August 1980) | Download Citation

Subjects

Abstract

Complete or ‘true’ hydatidiform mole, an abnormality of human gestation, is characterized by hydropic degeneration of all placental villi, marked hypertrophy of the trophoblast, absence of a fetus and a propensity to become malignant. The chromosome constitution of complete moles is usually 46,XX1,2, and Kajii et al. reported that the entire genome in seven out of seven cases was paternal in origin, with all centromere markers homozygous for paternal heteromorphisms3. These observations, since confirmed4,5, can be explained by the fertilization of an ‘empty’ egg—no effective genome—by either a haploid sperm that then duplicates without cytokinesis, to restore the diploid number, or by a diploid sperm resulting from failure of the second meiotic division. We report here a study of a series of complete moles that shows the first alternative to be correct in the majority of cases.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1.

    , & Am. J. Obstet. Gynec. 127, 167–170 (1977).

  2. 2.

    & Am. J. Obstet. Gynec. 132, 20–27 (1978).

  3. 3.

    & Nature 268, 633–634 (1977).

  4. 4.

    , , & Lancet ii, 49 (1978).

  5. 5.

    , & J. natn. Cancer Inst. 51–57 (1978).

  6. 6.

    & The Genetics of Human Populations (Freeman, San Francisco, 1971).

  7. 7.

    , , , & Am. J. Hum. Genet. 31, 680–696 (1979).

  8. 8.

    , , & C.r.hebd. Séanc. Acad. Sci. Paris 216, 3179–3181. (1973).

  9. 9.

    , , , & Am. J. Obstet. Gynec. 135, 597–600 (1979).

  10. 10.

    et al. Lancet ii, 580 (1979).

  11. 11.

    , & Hum. Genet. 51, 153–156 (1979).

  12. 12.

    , & Hum. Genet. 52, 203–210 (1979).

  13. 13.

    Expl Cell Res. 75, 304–306 (1972).

  14. 14.

    Humangenetik 17, 49–55 (1972).

Download references

Author information

Affiliations

  1. Department of Anatomy and Reproductive Biology, University of Hawaii School of Medicine, Honolulu, Hawaii 96822

    • Patricia A. Jacobs
    •  & Carola M. Wilson
  2. Departments of Pediatrics, Johns Hopkins University, Baltimore, Maryland 21210

    • Joyce A. Sprenkle
    •  & Barbara R. Migeon
  3. Gynecology and Obstetrics, Johns Hopkins University, Baltimore, Maryland 21210

    • Neil B. Rosenshein

Authors

  1. Search for Patricia A. Jacobs in:

  2. Search for Carola M. Wilson in:

  3. Search for Joyce A. Sprenkle in:

  4. Search for Neil B. Rosenshein in:

  5. Search for Barbara R. Migeon in:

About this article

Publication history

Received

Accepted

Published

DOI

https://doi.org/10.1038/286714a0

Further reading

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.