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Two types of somatic recombination are necessary for the generation of complete immunoglobulin heavy-chain genes

Nature volume 286, pages 676683 (14 August 1980) | Download Citation

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Abstract

At least two types of somatic recombination are necessary for the generation of a complete immunoglobulin γ2b gene from germ-line DNA sequences. The first type of recombination consists of the assembly of three separate DNA segments, each encoding a different part of the variable region. The second type of recombination replaces the exons coding for the constant region of the μ chain with those coding for the same region of the -γ2b chain. The DNA sequencing studies suggest that the two types of recombination operate by different mechanisms.

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  1. Basel Institute for Immunology, 487 Grenzacherstrasse, Postfach CH 4005, Basel 5, Switzerland

    • Hitoshi Sakano
    • , Richard Maki
    • , Yoshikazu Kurosawa
    • , William Roeder
    •  & Susumu Tonegawa

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https://doi.org/10.1038/286676a0

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