Abstract
The IF2 immunoglobulin mutant is a DNA deletion of one coding segment and large sections of the flanking intervening sequences. The deletion results in a new splicing pattern and starts in a DNA region containing tandemly repeated sequences which may carry heavy-chain class switch signals.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Adetugbo, K., Milstein, C. & Secher, D. S. Nature 265, 299–304 (1977).
Cotton, R. G. H., Secher, D. S. & Milstein, C. Eur. J. Immun. 3, 135–140 (1973).
Cowan, N. J., Secher, D. S. & Milstein, C. Eur. J. Biochem. 61, 355–368 (1976).
Dunnick, W., Rabbitts, T. H. & Milstein, C. Nucleic Acids Res. 8, 1475–1484 (1980).
Potter, M. in Methods in Cancer Research Vol. 2 (ed. Burch, H.) 105–132 (Academic, New York, 1967).
Horibata, K. & Harris, A. W. Expl Cell Res. 60, 61–77 (1970).
Franklin, E. C. & Frangione, B. in Contemporary Topics in Molecular Immunology (ed. Inman, F. P.) 89–126 (Plenum, New York, 1975).
Franklin, E. C. J. Immun. 121, 2582–2583 (1978).
Sakano, H. et al. Nature 277, 627–633 (1979).
Honjo, T. et al. Cell 18, 559–568 (1979).
Rabbitts, T. H. et al. Nature 283, 351–356 (1980).
Blattner, F. R. et al. Science 196, 161–169 (1977).
Schreier, P. G. & Cortese, R. J. molec. Biol. 129, 169–172 (1979).
Sanger, F. et al. J. molec. Biol. (submitted).
Maxam, A. & Gilbert, W. Proc. natn. Acad. Sci. U.S.A. 74, 560–564 (1977).
Lerner, M. R. et al. Nature 283, 220–224 (1980).
Catterall, J. F. et al. Nature 257, 510–513 (1978).
Breathnach, R. et al. Proc. natn. Acad. Sci. U.S.A. 75, 4953–4857 (1978).
Frangione, B. & Franklin, E. C. Nature 281, 600–602 (1979).
Pernis, B., Forni, L. & Luizzati, A. L. Cold Spring Harb. Symp. quant. Biol. 41, 175–183 (1976).
Wang, A. C. et al. Proc. natn. Acad. Sci. U.S.A. 66, 337–343 (1970).
Sledge, C. et al. Proc. natn. Acad. Sci. U.S.A. 73, 923–927 (1976).
Gearhart, P. J. Nature 269, 812–813 (1977).
Davis, M. M. et al. Nature 283, 733–739 (1980).
Bernard, O., Hozumi, N. & Tonegawa, S. Cell 15, 1133–1144 (1978).
Seidman, J. G. & Leder, P. Nature 276, 790–795 (1978).
Sakano, H. et al. Nature 280, 288–294 (1979).
Max, E. E., Seidman, J. G. & Leder, P. Proc. natn. Acad. Sci. U.S.A. 76, 3450–4354 (1979).
Rabbitts, T. H. & Matthyssens, G. Proc. natn. Acad. Sci. U.S.A. (submitted).
Kataoka, T. et al. Proc. natn. Acad. Sci. U.S.A. 77, 919–923 (1980).
Cory, S. & Adams, J. M. Cell 19, 37–52 (1980).
Coleclough, C., Cooper, D. & Perry, R. P. Proc. natn. Acad. Sci. U.S.A. 77, 1422–1426 (1980).
Honjo, T. & Kataoka, T. Proc. natn. Acad. Sci. U.S.A. 75, 2140–2144 (1978).
Yamawaki-Kataoka, Y. et al. Nature 283, 786–789 (1980).
Milstein, C. et al. in Cellular Selection and Regulation in the Immune Response (ed. Edelman, G. M.) 245–264 (Raven, New York, 1974).
Wang, J. C. in DNA Synthesis, Present and Future (eds Molineux, I. & Kohrijama, M.) 347–366 (Plenum, New York, 1978).
Tinoco, I. et al. Nature new Biol. 246, 40–41 (1973).
Rabbitts, T. H., Hamlyn, P. H. & Matthyssens, G. & Roe, B. Can. J. Biochem. 58, 76–187 (1980).
Sakano, H., Maki, R., Kurosawa, Y., Roeder, W. & Tonegawa, S. Nature 286, 676–683 (1980).
Southern, E. M. J. molec. Biol. 98, 503–517 (1975).
Wahl, G. M., Stern, M. & Stark, G. R. Proc. natn. Acad. Sci. U.S.A. 76, 3683–3687 (1979).
Jeffreys, A. J. & Flavell, R. A. Cell 12, 429–439 (1977).
Laskey, R. A. & Mills, A. D. FEBS Lett. 82, 314–316 (1979).
Maniatis, T. et al. Cell 15, 687–701 (1978).
Hohn, B. & Murray, K. Proc. natn. Acad. Sci. U.S.A. 74, 3259–3263 (1977).
Blattner, F. R. et al. Science 202, 1279–1280 (1978).
Benton, W. D. & Davis, R. W. Science 196, 180–182 (1977).
Bolivary, F. et al. Gene 2, 95–113 (1977).
Baralle, F. E., Shoulders, C. C. & Proudfoot, N. J. Cell (in the press).
Messing, J. et al. Proc. natn. Acad. Sci. U.S.A. 74, 3642–3646 (1977).
Cowan, N. J., Secher, D. S. & Milstein, C. J. molec. Biol. 90, 691–701 (1974).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Dunnick, W., Rabbitts, T. & Milstein, C. An immunoglobulin deletion mutant with implications for the heavy-chain switch and RNA splicing. Nature 286, 669–675 (1980). https://doi.org/10.1038/286669a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/286669a0
This article is cited by
-
A new case of γ-heavy chain disease (LIA protein) with deletion of the hinge region
La Ricerca in Clinica e in Laboratorio (1984)
-
Production of RNA for secreted immunoglobulin μ chains does not require transcriptional termination 5′ to the μM exons
Nature (1983)
-
Expression of lymphocyte surface IgE does not require switch recombination
Nature (1982)
-
Inherited deletion of immunoglobulin heavy chain constant region genes in normal human individuals
Nature (1982)
-
A model for the molecular requirements of immunoglobulin heavy chain class switching
Nature (1982)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
