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An immunoglobulin deletion mutant with implications for the heavy-chain switch and RNA splicing

Nature volume 286, pages 669675 (14 August 1980) | Download Citation

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Abstract

The IF2 immunoglobulin mutant is a DNA deletion of one coding segment and large sections of the flanking intervening sequences. The deletion results in a new splicing pattern and starts in a DNA region containing tandemly repeated sequences which may carry heavy-chain class switch signals.

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References

  1. 1.

    , & Nature 265, 299–304 (1977).

  2. 2.

    , & Eur. J. Immun. 3, 135–140 (1973).

  3. 3.

    , & Eur. J. Biochem. 61, 355–368 (1976).

  4. 4.

    , & Nucleic Acids Res. 8, 1475–1484 (1980).

  5. 5.

    in Methods in Cancer Research Vol. 2 (ed. Burch, H.) 105–132 (Academic, New York, 1967).

  6. 6.

    & Expl Cell Res. 60, 61–77 (1970).

  7. 7.

    & in Contemporary Topics in Molecular Immunology (ed. Inman, F. P.) 89–126 (Plenum, New York, 1975).

  8. 8.

    J. Immun. 121, 2582–2583 (1978).

  9. 9.

    et al. Nature 277, 627–633 (1979).

  10. 10.

    et al. Cell 18, 559–568 (1979).

  11. 11.

    et al. Nature 283, 351–356 (1980).

  12. 12.

    et al. Science 196, 161–169 (1977).

  13. 13.

    & J. molec. Biol. 129, 169–172 (1979).

  14. 14.

    et al. J. molec. Biol. (submitted).

  15. 15.

    & Proc. natn. Acad. Sci. U.S.A. 74, 560–564 (1977).

  16. 16.

    et al. Nature 283, 220–224 (1980).

  17. 17.

    et al. Nature 257, 510–513 (1978).

  18. 18.

    et al. Proc. natn. Acad. Sci. U.S.A. 75, 4953–4857 (1978).

  19. 19.

    & Nature 281, 600–602 (1979).

  20. 20.

    , & Cold Spring Harb. Symp. quant. Biol. 41, 175–183 (1976).

  21. 21.

    et al. Proc. natn. Acad. Sci. U.S.A. 66, 337–343 (1970).

  22. 22.

    et al. Proc. natn. Acad. Sci. U.S.A. 73, 923–927 (1976).

  23. 23.

    Nature 269, 812–813 (1977).

  24. 24.

    et al. Nature 283, 733–739 (1980).

  25. 25.

    , & Cell 15, 1133–1144 (1978).

  26. 26.

    & Nature 276, 790–795 (1978).

  27. 27.

    et al. Nature 280, 288–294 (1979).

  28. 28.

    , & Proc. natn. Acad. Sci. U.S.A. 76, 3450–4354 (1979).

  29. 29.

    & Proc. natn. Acad. Sci. U.S.A. (submitted).

  30. 30.

    et al. Proc. natn. Acad. Sci. U.S.A. 77, 919–923 (1980).

  31. 31.

    & Cell 19, 37–52 (1980).

  32. 32.

    , & Proc. natn. Acad. Sci. U.S.A. 77, 1422–1426 (1980).

  33. 33.

    & Proc. natn. Acad. Sci. U.S.A. 75, 2140–2144 (1978).

  34. 34.

    et al. Nature 283, 786–789 (1980).

  35. 35.

    et al. in Cellular Selection and Regulation in the Immune Response (ed. Edelman, G. M.) 245–264 (Raven, New York, 1974).

  36. 36.

    in DNA Synthesis, Present and Future (eds Molineux, I. & Kohrijama, M.) 347–366 (Plenum, New York, 1978).

  37. 37.

    et al. Nature new Biol. 246, 40–41 (1973).

  38. 38.

    , & & Can. J. Biochem. 58, 76–187 (1980).

  39. 39.

    , , , & Nature 286, 676–683 (1980).

  40. 40.

    J. molec. Biol. 98, 503–517 (1975).

  41. 41.

    , & Proc. natn. Acad. Sci. U.S.A. 76, 3683–3687 (1979).

  42. 42.

    & Cell 12, 429–439 (1977).

  43. 43.

    & FEBS Lett. 82, 314–316 (1979).

  44. 44.

    et al. Cell 15, 687–701 (1978).

  45. 45.

    & Proc. natn. Acad. Sci. U.S.A. 74, 3259–3263 (1977).

  46. 46.

    et al. Science 202, 1279–1280 (1978).

  47. 47.

    & Science 196, 180–182 (1977).

  48. 48.

    et al. Gene 2, 95–113 (1977).

  49. 49.

    , & Cell (in the press).

  50. 50.

    et al. Proc. natn. Acad. Sci. U.S.A. 74, 3642–3646 (1977).

  51. 51.

    , & J. molec. Biol. 90, 691–701 (1974).

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  1. MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK

    • W. Dunnick
    • , T. H. Rabbitts
    •  & C. Milstein

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https://doi.org/10.1038/286669a0

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