Letter | Published:

Control of tension development in scallop muscle fibres with foreign regulatory light chains

Naturevolume 286pages626628 (1980) | Download Citation



We have shown previously that chemically skinned fibre bundles from scallop muscle can be desensitized to the action of calcium by the removal of the regulatory light chains of myosin and that sensitivity can be restored by the re-addition of scallop light chains1. We have now confirmed these results and extended our observations to fibre bundles from which one or both of the regulatory light chains per myosin have been removed (by treatment with EDTA at 7 and 25 °C, respectively) and replaced by the corresponding light chains from other species. In the case of a double substitution—where both light chains were replaced—sensitivity was restored completely by light chains from other molluscs and from gizzard muscle; for a single substitution there was restoration of sensitivity by all the light chains tested.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.


  1. 1

    Simmons, R. M. & Szent-Györgyi, A. G. Nature 273, 62–64 (1978).

  2. 2

    Chantler, P. D. & Szent-Györgyi, A. G. J. molec. Biol. 138, 473–492 (1980).

  3. 3

    Kendrick-Jones, J. Nature 249, 631–634 (1974).

  4. 4

    Kendrick-Jones, J., Szentkiralyi, E. M. & Szent-Györgyi, A. G. J. molec. Biol. 104, 747–775 (1976).

  5. 5

    Chantler, P. D., Sellers, J. R. & Szent-Györgyi, A. G. Biophys. J. 25, 92a (1979).

  6. 6

    Moisescu, D. G. Nature 262, 610–613 (1976).

Download references

Author information


  1. Department of Physiology, University College London, Gower Street, London, WC1E 6BT, UK

    • R. M. Simmons
    •  & A. G. Szent-Györgyi
  2. Department of Biology, Brandeis University, Waltham, Massachusetts, 02154

    • R. M. Simmons
    •  & A. G. Szent-Györgyi


  1. Search for R. M. Simmons in:

  2. Search for A. G. Szent-Györgyi in:

About this article

Publication history



Issue Date



Further reading


By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.