Abstract
A mouse α-globin-related pseudogene (ψα30.5) completely lacks intervening sequences, and could not code for a functional globin polypeptide because of frameshifts. The widespread occurrence of globin pseudogenes in other species suggests that they are not ‘dead’ genes but may be important in controlling globin expression.
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References
Breathnach, R., Mandel, J. L. & Chambon, P. Nature 270, 314–319 (1977).
Brack, C. & Tonegawa, S. Proc. natn. Acad. Sci. U.S.A. 74, 5652–5656 (1977).
Leder, P. et al. Cold Spring Harb. Symp. quant. Biol. 42, 915–920 (1977).
Jeffreys, A. J. & Flavell, R. A. Cell 12, 1097–1108 (1977).
Lomedico, P. et al. Cell 18, 545–558 (1979).
Crick, F. Science 204, 264–271 (1979).
Abelson, J. A. Rev. Biochem. 48, 1035–1069 (1979).
Leder, A. et al. Proc. natn. Acad. Sci. U.S.A. 75, 6187–6191 (1978).
Nishioka, Y. & Leder, P. Cell 18, 875–882 (1979).
Tilghman, S. M. et al. Proc. natn. Acad. Sci. U.S.A. 74, 4406–4410 (1977).
Konkel, D. A., Tilghman, S. M. & Leder, P. Cell 15, 1125–1132 (1978).
Tiemeier, D. C. et al. Cell 14, 237–245 (1978).
Konkel, D. A., Maizel, J. V. Jr & Leder, P. Cell 18, 865–873 (1979).
van den Berg, J. et al. Nature 276, 37–44 (1978).
Dodgson, J. B., Strommer, J. & Engel, J. D. Cell 17, 879–887 (1979).
Lawn, R. M., Fritsch, E. F., Parker, R. C., Blake, G. & Maniatis, T. Cell 15, 1157–1174 (1978).
Slightom, J. L., Blechl, A. E. & Smithies, O. Cell (in the press).
Lauer, J., Shen, C.-K. J. & Maniatis, T. Cell 20, 119 (1980).
Blattner, F. R. et al. Science 202, 1279–1284 (1978).
Smithies, O. et al. Science 202, 1284–1289 (1978).
Lacy, E., Hardison, R. C., Quon, D. & Maniatis, T. Cell 18, 1273–1283 (1979).
Hardison, R. C. et al. Cell 18, 1285–1297 (1979).
Fritsch, E. F., Lawn, R. M. & Maniatis, T. Cell 19, 959–972 (1980).
Melderis, H., Steinheider, G. & Ostertag, W. Nature 250, 774–776 (1974).
Heindel, H. C., Liu, A., Paddock, G. V., Studnicka, G. M. & Salser, W. A. Cell 15, 43–54 (1978).
Pavlakis, G. N. et al. Cell 19, 91–102 (1980).
Pribnow, D. Proc. natn. Acad. Sci. U.S.A. 72, 784–788 (1975).
Ziff, E. B. & Evans, R. M. Cell 15, 1463–1475 (1978).
Proudfoot, N. J. & Brownlee, G. G. Nature 263, 211–214 (1976).
Dayhoff, M. O. (ed.) in Atlas of Protein Sequence and Structure Vol. 5, Suppl. 2, 191–223 (National Biomedical Research Foundation, Washington, DC, 1976).
Perler, F. et al. Cell (in the press).
Cordell, B. et al. Cell 18, 533–543 (1979).
Bell, G. I. et al. Nature 284, 26–32 (1980).
Temin, H. M. A. Rev. Genet. 8, 155–177 (1974).
Nevins, J. R. & Darnell, J. E. Cell 15, 1477–1493 (1978).
Hamer, D. H., Smith, K. D., Boyer, S. H. & Leder, P. Cell 17, 725–735 (1979).
Hamer, D. H. & Leder, P. Cell 17, 737–747 (1979); 18, 1299–1302 (1979).
Davidson, E. H. & Britten, R. J. Science 204, 1052–1059 (1979).
Lerner, M. R., Boyle, J. A., Mount, S. M., Wolin, S. I. & Steitz, J. A. Nature 283, 220–224 (1980).
Rogers, J. & Wall, R. Proc. natn. Acad. Sci. U.S.A. 77, 1877 (1980).
Berk, A. J. & Sharp, P. A. Cell 12, 721–732 (1977).
Maxam, A. M. & Gilbert, W. Proc. natn. Acad. Sci. U.S.A. 74, 560–564 (1977).
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Vanin, E., Goldberg, G., Tucker, P. et al. A mouse α-globin-related pseudogene lacking intervening sequences. Nature 286, 222–226 (1980). https://doi.org/10.1038/286222a0
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DOI: https://doi.org/10.1038/286222a0
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