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The role of D-1 and D-2 receptors

Nature volume 286, pages 157–159 (1980)Cite this article

Abstract

Dopamine receptors in intracerebral motor and endocrine systems1,2 have been divided into two main types, D-1 and D-2, dependent on the presence or absence of adenylate cyclase linkage3. Here we have investigated a number of dopamine agonist and antagonist drugs in man that have different actions on D-1 and D-2 receptors in animals. Motor and endocrine effects in parkinsonian subjects seem to depend on drug interaction with D-2, but not D-1, receptors. These results may have important implications for the design of anti-parkinsonian and antipsychotic agents.

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Authors and Affiliations

  1. University Department of Neurology, King's College Hospital and Institute of Psychiatry, London, SE5 9RS, UK

    M. Schachter, P. Bédard, A. G. Debono, P. Jenner, C. D. Marsden, P. Price & J. D. Parkes

  2. Department of Chemical and Clinical Pathology, King's College Hospital, Royal Bethlem and Maudsley Hospitals, London, SE5 8AZ

    J. Keenan & B. Smith

  3. Sandoz, Basle, Switzerland

    J. Rosenthaler

  4. Schering, Berlin, FRG

    R. Horowski & R. Dorow

Authors
  1. M. Schachter
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  2. P. Bédard
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  3. A. G. Debono
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  4. P. Jenner
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  5. C. D. Marsden
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  6. P. Price
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  7. J. D. Parkes
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  8. J. Keenan
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  10. J. Rosenthaler
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  11. R. Horowski
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  12. R. Dorow
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Schachter, M., Bédard, P., Debono, A. et al. The role of D-1 and D-2 receptors. Nature 286, 157–159 (1980). https://doi.org/10.1038/286157a0

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