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Deletions in the constant region locus can account for switches in immunoglobulin heavy chain expression

Nature volume 285, pages 450–456 (1980)Cite this article

Abstract

Deletions spanning portions of the heavy chain constant region (CH) locus in murine plasmacytomas are revealed by hybridization with cloned immunoglobulin DNA molecules. The pattern of deletions suggests that a lymphocyte clone switches expression of CH genes by successive deletions and that the probable CH gene order is 5′ µ-γ3-γ1-γ2b-γ2a-α3′.

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Authors and Affiliations

  1. The Walter and Eliza Hall Institute of Medical Research, Post Office, Royal Melbourne Hospital, Victoria, 3050, Australia

    Suzanne Cory, Jillian Jackson & Jerry M. Adams

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  1. Suzanne Cory
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  2. Jillian Jackson
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  3. Jerry M. Adams
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Cory, S., Jackson, J. & Adams, J. Deletions in the constant region locus can account for switches in immunoglobulin heavy chain expression. Nature 285, 450–456 (1980). https://doi.org/10.1038/285450a0

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