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Mechanism of action of dietary fibre in the human colon

Nature volume 284, pages 283–284 (1980)Cite this article

Abstract

Fibre, more than any other dietary component, affects human large bowel function, causing an increase in stool output, dilution of colonic contents, a faster rate of passage through the gut and changes in the colonic metabolism of minerals, nitrogen and bile acids1–6. (Fibre here refers to ‘dietary fibre’, which comprises plant cell wall polysaccharides and lignin, and not to ‘crude fibre’.) It is thought that these changes are brought about by fibre passing through the gut undigested and holding water within its cellular structure7,8. Although the amount of water taken up in vitro varies for different types of fibre8–10, this does not correlate in the expected way with the effects these materials have on colonic function9. This is because fibre is extensively degraded in the gut2,11, probably by the colonic microflora12,13. Using a newly developed method modified from ruminant nutrition for isolating bacteria, we have shown that the main component of human faeces is bacteria14. We show here that the way in which two contrasting types of dietary fibre act in the colon depends on the extent to which they are digested. Cabbage fibre, which is extensively broken down, provides a readily usable substrate for the stimulation of microbial growth, whereas wheat fibre remains largely undigested and retains water in the gut lumen.

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References

  1. Cummings, J. H. et al. Lancet i, 5–8 (1978).

    Article  Google Scholar 

  2. Southgate, D. A. T. et al. Metabolism 25, 1129–1135 (1976).

    Article  CAS  Google Scholar 

  3. Cummings, J. H., Hill, M. J., Jenkins, D. J. A., Pearson, J. R. & Wiggins, H. S. Am. J. clin. Nutr. 29, 1468–1473 (1976).

    Article  CAS  Google Scholar 

  4. Cummings, J. H. et al. Am. J. din. Nutr. 32, 2086–2093 (1979).

    Article  CAS  Google Scholar 

  5. Cummings, J. H., Hill, M. J., Bone, E. S., Branch, W. J. & Jenkins, D. J. A. Am. J. clin. Nutr. 32, 2094–2101 (1979).

    Article  CAS  Google Scholar 

  6. Eastwood, M. A., Kirkpatrick, J. R., Mitchell, W. D., Bone, A. & Hamilton, T. Br. med. J. IV, 392–394 (1973).

    Article  Google Scholar 

  7. Eastwood, M. A. & Mitchell, W. D. in Fiber in Human Nutrition (eds Spiller, G. A. & Amen, R. J.) 109–130 (Plenum, New York, 1976).

    Book  Google Scholar 

  8. McConnell, A. A., Eastwood, M. A. & Mitchell, W. D. J. Sci. Fd Agric. 25, 1457–1464 (1974).

    Article  CAS  Google Scholar 

  9. Stephen, A. M. & Cummings, J. H. Gut 20, 722–729 (1979).

    Article  CAS  Google Scholar 

  10. Heller, S. N. thesis, Cornell Univ. (1978).

  11. Cummings, J. H. et al. Br. J. Nutr. 41, 477–485 (1979).

    Article  CAS  Google Scholar 

  12. Bryant, M. P. Am. J. clin. Nutr. 31, S113–S115 (1978).

    Article  CAS  Google Scholar 

  13. Salyers, A. A., Vercellotti, J. R., West, S. E. H. & Wilkins, T. D. Appl. envir. Microbiol. 33, 319–322 (1977).

    CAS  Google Scholar 

  14. Stephen, A. M. & Cummings, J. H. J. med. Microbiol. (in the press).

  15. Luria, S. E. in The Bacteria (eds Gunsalus, I. C. & Stanier, R. Y.) 1–34 (Academic, New York, 1960).

    Google Scholar 

  16. Dintzis, F. R., McBrien, J. B., Baker, F. L. & Inglett, C. E. in Dietary Fibers: Chemistry and Nutrition (eds Inglett, G. E. & Falkehag, S. I.) 157–171 (Academic, New York, 1979).

    Book  Google Scholar 

  17. Williams, A. E., Eastwood, M. A. & Cregeen, R. Scanning Electron Microsc. II, 707–712 (1978).

    Google Scholar 

  18. Stephen, A. M. & Cummings, J. H. Proc. Nutr. Soc. 38, 141A (1979).

    CAS  PubMed  Google Scholar 

  19. Southgate, D. A. T. & Durnin, J. V. G. A. Br. J. Nutr. 24, 517–535 (1970).

    Article  CAS  Google Scholar 

  20. Kay, R. M. & Truswell, A. S. Br. J. Nutr. 37, 227–235 (1977).

    Article  CAS  Google Scholar 

  21. Cummings, J. H. Topics Gastroenterol. 6, 49–62 (1978).

    Google Scholar 

  22. Kritchevsky, D. & Story, J. A. J. Nutr. 104, 458–462 (1974).

    Article  CAS  Google Scholar 

  23. Eastwood, M. A., Anderson, R., Mitchell, W. D., Robertson, J. & Pocock, S. J. Nutr. 106, 1429–1432 (1976).

    Article  CAS  Google Scholar 

  24. Burkitt, D. P., Walker, A. R. P. & Painter, N. S. Lancet ii, 1408–1412 (1972).

    Article  Google Scholar 

  25. Cummings, J. H., Jenkins, D. J. A. & Wiggins, H. S. Gut 17, 210–218 (1976).

    Article  CAS  Google Scholar 

  26. Goering, H. K. & Van Soest, P. J. Agric. Handb. Forest Serv. 379, 1–20 (1970).

    Google Scholar 

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  1. Dunn Clinical Nutrition Centre, Addenbrookes Hospital, Trumpington Street, Cambridge, CB2 1QE, UK

    Alison M. Stephen & John H. Cummings

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  1. Alison M. Stephen
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  2. John H. Cummings
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Stephen, A., Cummings, J. Mechanism of action of dietary fibre in the human colon. Nature 284, 283–284 (1980). https://doi.org/10.1038/284283a0

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