Letter | Published:

Herpes simplex virus depresses antibody production by affecting T-cell function

Abstract

Many viruses enter lympho-reticular cells during pathogenesis and thereby induce immunosuppression1, which is of practical importance in that it may be related to overall virulence2. Immunosuppression may result from a selective infection, as viruses often show an affinity for different lymphocyte sub-populations: Epstein–Barr virus, for example, infects only a small percentage of B cells3. We reported previously that herpes simplex virus (HSV) type 1 suppressed the induction of an antibody response to diptheria toxoid in cultures of human tonsil cells, and that this seemed to result from the infection of a small percentage of T lymphocytes4. However, as fully infectious virus was used in these experiments, it had probably spread from cell to cell in the course of the culture, so complicating the interpretation of the results. Accordingly, we have now re-investigated the mechanism of immunosuppression using temperature-sensitive (ts) mutants which fail to complete their growth cycle in the conditions selected for antibody synthesis. In this study, mutants tsB, tsD and tsF, derived from HSV type 1 strain 17, and ts 9, derived from HSV type 2 HG 52, were used. The results suggest that the immunosuppression is due to the selective infection by the viruses of helper T cells.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1

    Notkins, A. L., Mergenhagen, S. E. & Howard, R. J. A. Rev, Microbiol. 24, 525–538 (1970).

  2. 2

    Wiktor, T. J., Doherty, P. C. & Koprowski, H. J. exp. Med. 145, 1617–1622 (1977).

  3. 3

    Menezes, J., Jondal, M., Leibold, W. & Dorval, G. Infect. Immun, 13, 303–310 (1976).

  4. 4

    Pelton, B. K., Imrie, R. C. & Denman, A. M. Immunology 32, 803–810 (1977).

  5. 5

    Janossy, G., De la Concha, E. G., Waxdal, M. J. & Platts-Mills, T. A. E. Clin. exp. Immun. 26, 108–117 (1976).

  6. 6

    De la Concha, E. G., Oldham, G., Webster, A. D. W., Asherson, G. L. & Platts-Mills, T. A. E. Clin. exp. Immun. 27, 208–215 (1977).

  7. 7

    Gmelig-Meyling, F. & Ballieux, R. E. Vox Sang. 33, 5–8 (1977).

  8. 8

    Brown, G. & Greaves, M. F. Eur. J. Immun. 4, 302–310 (1974).

Download references

Author information

Rights and permissions

Reprints and Permissions

About this article

Further reading

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.