Abstract
Incompatibility between ColE1 plasmids in Escherichia coli can be explained by competition for a limited number of replication sites. These sites ensure directive segregation of plasmids to daughter cells on cell division. The number of sites can be more than one only if a linear segregation mechanism is postulated.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Rent or buy this article
Get just this article for as long as you need it
$39.95
Prices may be subject to local taxes which are calculated during checkout
References
Jacob, F., Brenner, S. & Cuzin, F. Cold Spring Harb. Symp. quant. Biol. 28, 329–348 (1963).
Pritchard, R. H., Barth, P. T. & Collins, J. Symp. Soc. gen. Microbiol. 19, 263–297 (1969).
Pritchard, R. H., Chandler, M. G. & Collins, J. Molec. gen. Genet. 138, 143–155 (1975).
Inselburg, J. J. Bact. 119, 478–483 (1974).
Smith, H.R., Humphreys, G.O. & Anderson, E.S. Molec. gen. Genet. 129, 229–242 (1974).
Warren, G. & Sherratt, D.J. Molec. gen. Genet. 151, 197–207 (1977).
Bazaral, M. & Helsinki, D.R. Biochemistry 9, 399–406 (1970).
Cabello, F., Timmis, K. & Cohen, S.N. Nature 259, 285–290 (1976).
Cohen, S. N. & Chang, A. C. Y. Proc. natn. Acad. Sci. U.S.A. 70, 1293–1297 (1973).
Heffron, F., Sublett, R., Hedges, R. W., Jacob, A. & Falkow, S. J. Bact. 122, 250–256 (1975).
Rodriquez, R. L., Bolivar, F., Goodman, H.M., Boyer, H. W. & Betlach, M. C. Molecular Mechanisms in the Control of Gene Expression (eds Nierlich, D.P., Rutter, W.J. & Fox, C.) 471 (Academic, New York, 1976).
Hershfield, V., Boyer, H. W., Chow, L. & Helinski, D. R. J. Bact. 126, 447–453 (1976).
So, M., Gill, R. & Falkow, S. Molec. gen. Genet. 142, 239–249 (1976).
Bedbrook, J. R. & Ausubel, F.M. Cell 9, 707–716 (1976).
Collins, J., Yanofsky, S. & Helinski, D. R. Molec. gen. Genet. 167, 21–28 (1978).
Boyer, H. W. & Roulland-Dossaix, D. J. molec. Biol. 41, 459–472 (1969).
Bedbrook, J. R. & Bogorad, L. Proc. natn. Acad. Sci. U.S.A. 73, 4309–4313 (1977).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Bedbrook, J., Lehrach, H. & Ausubel, F. Directive segregation is the basis of ColE1 plasmid incompatibility. Nature 281, 447–452 (1979). https://doi.org/10.1038/281447a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/281447a0
This article is cited by
-
Preferential replication-dependent mutagenesis in the lagging DNA strand inEscherichia coli
Molecular and General Genetics MGG (1996)
-
Tn1000 insertional mutagenesis of cloned repressor gene of the phage L: Plasmid oligomerization in the presence of F’lac
Folia Microbiologica (1987)
-
Base pairing of RNA I with its complementary sequence in the primer precursor inhibits ColE1 replication
Nature (1981)
-
The target of the negative regulator of pMB1 replication overlaps with part of the repressor coding sequence
Molecular and General Genetics MGG (1981)
-
Site-specific properties of Tn7 transposition into the E. coli Chromosome
Molecular and General Genetics MGG (1981)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
