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Superoxide involvement in the bactericidal effects of negative air ions on Staphylococcus albus

Abstract

The physical nature of small air ions is well established and it is recognised that they can produce a variety of biological effects1. However, in only a few instances have any underlying biochemical changes been detected2–4. Theoretically, one can consider the hydrated Superoxide radical anion (O2) (H2O)n with n4–8 as a likely candidate for a biologically active species of negative air ion5. The chemical and biological reactivity of Superoxide is high6 and includes a leading role in bacterial killing caused by radiation7,8, in which Superoxide dismutase (SOD), an enzyme that catalyses the reaction: O2+O22H→H2O2+O2 protected markedly. Other studies have also demonstrated the bactericidal effect of O2 (refs 9–11). Inasmuch as the bactericidal action of small negative air ions has been repeatedly confirmed, we decided to test for the involvement of O2 in this phenomenon by evaluating the protective effect of SOD. Our results show strong O2 involvement in negative air ion bacterial kill.

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Kellogg, E., Yost, M., Barthakur, N. et al. Superoxide involvement in the bactericidal effects of negative air ions on Staphylococcus albus. Nature 281, 400–401 (1979). https://doi.org/10.1038/281400a0

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