Abstract
Agrobacterium tumefaciens induces tumours in dicotyledonous plants by transferring part of a large bacterial plasmid to the eukaryotic cell. As well as disrupting control of cell division, the transferred DNA determines the synthesis in transformed tissue of novel amino acid compounds which serve as specific substrates for the bacterium. It may prove possible to exploit such DNA transfer for the genetic engineering of higher plants.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Rent or buy this article
Get just this article for as long as you need it
$39.95
Prices may be subject to local taxes which are calculated during checkout
References
Smith, E. F. & Townsend, C. O. Science 25, 671–673 (1907).
White, P. R. & Braun, A. C. Cancer Res. 2, 597–617 (1942).
Elliott, C. in Manual of Bacterial Plant Pathogens 2nd edn 3–12 (Chronica Botanica, Waltham, Massachusetts, 1951).
Rack, K. Phytopath. Z. 21, 1 (1954).
Chilton, M.-D. et al. Cell 11, 263–271 (1977).
Braun, A. C. in The Cancer Problem, a Critical Analysis and Modern Synthesis (Columbia University Press, New York, 1969).
Goldmann-Menagé, A. Ann. Sci. Nat. Bot. Paris 12ème Ser. 11, 223–310 (1971).
Bomhoff, G. thesis, Univ. Leiden (1974).
Holderbach, E. & Beiderbeck, R. Phytochemistry 15, 955–959 (1976).
Kemp, J. D. Biochem. biophys. Res. Commun. 69, 816–822 (1976).
Zaenen, I. et al. J. molec. Biol. 86, 109–127 (1974).
Hamilton, R. H. & Fall, M. Z. Experientia 27, 229–230 (1971).
Schell, J. in Genetic Manipulations with Plant Material (ed. Ledoux, L.) 163–181 (Plenum, New York, 1974).
Chilton, M.-D. et al. in Modification of the Information Content of Plant Cells (eds Markham, Davies, Hopwood & Horne) 297–311 (Elsevier, New York, 1974).
Van Larebeke, N. et al. Nature 252, 169–170 (1974).
Watson, B. et al. J. Bact. 123, 255–264 (1975).
Van Larebeke, N. et al. Nature 255, 742–743 (1975).
Bomhoff, G. et al. Molec. gen. Genet. 145, 177–181 (1976).
Gordon, M. P. et al. in A Symposium on the Molecular Biology of Plants (ed. Rubenstein, I.) (University of Minnesota Press, 1976).
Schell, J. et al. in A Symposium on the Molecular Biology of Plants (ed. Rubenstein, I.) (University of Minnesota Press, 1976).
Chilton, M.-D. et al. Genetics 83, 609–618 (1976).
Goldmann, A., Tempé, J. & Morel, G. C.r. Séanc. Soc. Biol. Ses Fil. 162, 630–631 (1968).
Petit, A. et al. Physiol. Vég. 8, 205–213 (1970).
Klapwijk, P. M. et al. J. gen. Microbiol. 96, 155–163 (1976).
Montoya, A. L. et al. J. Bact. 129, 101–107 (1977).
Petit, A. & Tempé, J. Molec. gen. Genet. 167, 147–155 (1978).
Lejeune, B. C.r. hebd. Séanc. Acad. Sci., Paris B265, 1753–1755 (1967).
Jubier, M.-F. & Lejeune, B. Physiol. Vég. 10, 653–664 (1972).
Menagé, A. & Morel, G. C.r. hebd. Séanc. Acad. Sci., Paris 259, 4795–4796 (1964).
Lioret, C. C.r. hebd. Séanc. Acad. Sci., Paris 244, 2171–2174 (1957).
Biemann, K. et al. Biochim. biophys. Acta 40, 369–370 (1960).
Kemp, J. D. Biochem. biophys. Res. Commun. 74, 862–868 (1977).
Menagé, A. & Morel, G. C.r. Séanc. Soc. Biol., Paris 159, 561–562 (1965).
Firmin, J. L. & Fenwick, R. G. Phytochemistry 16, 761–762 (1977).
Firmin, J. L. & Fenwick, R. G. Nature 276, 842–844 (1978).
Klapwijk, P. M., Oudshoorn, M. & Schilperoort, R. A. J. gen. Microbiol. 102, 1–11 (1977).
Petit, A., Dessaux, Y. & Tempé, J. Proc. Fourth Int. Conf. Pl. Path. Bacteria (Angers, France, in the press).
Ellis, J. et al. Molec. gen. Genet. 173, 253–259 (1979).
Genetello, C. et al. Nature 265, 561–563 (1977).
Kerr, A., Manigault, P. & Tempé, J. Nature 265, 560–561 (1977).
Petit, A. et al. Nature 271, 570–571 (1978).
Hooykaas, P. J. J., Roobol, C. & Schilperoort, R. A. J. gen. Microbiol. 110, 99–109 (1979).
Tempé, J. & Schell, J. in Natural and Synthetic Polynucleotides (ed. Legocki, A. B.) 415–420 (Elsevier, New York, 1977).
Schell, J. & Van Montagu, M. in Conference on Genetic Engineering for Nitrogen Fixation (ed. Hollaender, A.) 159–179 (Brookhaven National Laboratory, Upton, New York, 1977).
Klapwijk, P. M., Scheulderman, T. & Schilperoort, R. A. J. Bact. 136, 775–785 (1978).
Schell, J. et al. Proc. 12th FEBS Mtng, Dresden (ed. Rapoport, S.) (Pergamon, Oxford, 1978).
Lippincott, J. A. & Lippincott, B. B. Science 170, 176–177 (1970).
Lippincott, J. A., Lippincott, B. B. & Chang, C. C. Pl. Physiol. 49, 131–137 (1972).
Lippincott, B. B., Whatley, M. H. & Lippincott, J. A. Pl. Physiol. 59, 388–390 (1977).
Lippincott, J. A. & Lippincott, B. B. Science 199, 1075–1078 (1978).
Braun, A. C. Growth 16, 65–74 (1952).
Lipetz, J. Cancer Res. 26, 1597–1605 (1966).
Tempé, J. et al. Proc. nat. Acad. Sci. U.S.A. 74, 2848–2849 (1977).
Sciaky, D., Montoya, A. L. & Chilton, M. D. Plasmid 1, 238–253 (1978).
Currier, T. C. & Nester, E. W. J. Bact. 126, 157–165 (1976).
Drummond, M. & Chilton, M. D. J. Bact. 136, 1178–1183 (1978).
Sonoki, S. et al. Proc. Fourth Int. Conf. Pl. Path. Bacteria (Angers, France, in the press).
Yang, F. M. et al. Molec. gen. Genet. (in the press).
DePicker, A., Van Montagu, M. & Schell, J. Nature 275, 150–153 (1978).
Chilton, M. D. et al. Nature 275, 147–149 (1978).
Chilton, M. D. et al. in Emergent Techniques for Plant Genome Modification (ed. Rubenstein, I.) (University of Minnesota Press, in the press).
Weinberg, R. A. Cell 11, 243–246 (1977).
Southern, E. M. J. molec. Biol. 98, 503–517 (1975).
Drummond, M. H. et al. Nature 269, 535–536 (1977).
Ledeboer, A. thesis, Univ. Leiden (1978).
Gurley, W. B. et al. Proc. natn. Acad. Sci. U.S.A. (in the press).
Jablonski, J. R. & Skoog, F. Physiologia Pl. 7, 16–24 (1954).
Skoog, F. & Armstrong, D. J. A. Rev. Pl. Physiol. 21, 359–384 (1970).
Black, L. M. Prog. exp. Tumor. Res. 15, 110–137 (1972).
Kehr, A. E. & Smith, H. H. Brookhaven Symp. Biol. 6, 55–76 (1954).
Hooykaas, P. J. J. et al. J. gen. Microbiol. 98, 477–484 (1977).
Braun, A. C. Proc. natn. Acad. Sci. U.S.A. 45, 932–938 (1959).
Braun, A. C. & Wood, H. N. Proc. natn. Acad. Sci. U.S.A. 73, 496–500 (1976).
Wood, H. N., Binns, A. N. & Braun, A. C. Differentiation 11, 175–180 (1978).
Turgeon, R., Wood, H. N. & Braun, A. C. Proc. natn. Acad. Sci. U.S.A. 73, 3562–3564 (1976).
Kleid, D. et al. Proc. natn. Acad. Sci. U.S.A. 73, 293–297 (1976).
MacHattie, L. A. & Jackowski, J. B. in DNA Insertion Elements, Plasmids and Episomes (eds Bukhari, A. I., Shapiro, J. A. & Adhya, S. L.) 219–228 (Cold Spring Harbor Laboratory, New York, 1977).
So, M. et. al. Nature 277, 453–456 (1979).
Berg, D. E. & Drummond, M. H. J. Bact. 136, 419–422 (1978).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Drummond, M. Crown gall disease. Nature 281, 343–347 (1979). https://doi.org/10.1038/281343a0
Published:
Issue Date:
DOI: https://doi.org/10.1038/281343a0
This article is cited by
-
Metabolic alterations of Verbascum nigrum L. plants and SAArT transformed roots as revealed by NMR-based metabolomics
Plant Cell, Tissue and Organ Culture (PCTOC) (2015)
-
Methylglyoxal destroys Agrobacterium tumefaciens crown gall tumours in Nicotiana tabacum without any adverse effect on the host plant
Biologia plantarum (2011)
-
Crown gall disease andAgrobacterium tumefaciens: A study of the history, present knowledge, missing information, and impact on molecular genetics
The Botanical Review (2000)
-
Crystal structure and active site location of N-(1-D-carboxylethyl)-L-norvaline dehydrogenase
Nature Structural Biology (1998)
-
Collective biology of neoplastic disease in dicotyledonous plants
Acta Biotheoretica (1987)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.