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A structurally abnormal insulin causing human diabetes


Insulin isolated from the pancreas of a diabetic patient with fasting hyperinsulinaemia showed decreased activity in binding to cell membrane insulin receptors and in stimulating cellular 2-deoxyglucose transport and glucose oxidation. Chemical studies suggest that the isolated hormone is a mixture of normal insulin and an abnormal variant which contains a leucine for phenylalanine substitution at position 24 or 25 of the insulin B-chain.

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Tager, H., Given, B., Baldwin, D. et al. A structurally abnormal insulin causing human diabetes. Nature 281, 122–125 (1979).

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