Abstract
THE oncogenic potential of herpesviruses has been demonstrated in several species and herpesviruses have been strongly implicated as aetiological agents of various human neoplastic diseases1,2. The extreme heterogeneity of human populations makes genetic analysis of mechanisms of host resistance to neoplastic disease in man a difficult task. Another herpesvirus, Marek's disease virus (MDV), is the aetiological agent of a naturally occurring lymphoma of chickens, Marek's disease (MD) (for review see ref. 3). MD is the animal model for Burkitt's lymphoma of man in which the Epstein-Barr virus (EBV) has been strongly implicated4. At least two loci are associated with resistance to MD: the major histocompatibility complex (MHC)5,6 and a non-MHC locus7. The mechanism of MHC-associated resistance may involve an active rejection of MD tumour cells5. We now report data which strongly suggest that non-MHC-associated genetic resistance is expressed at the level of the target cell for malignant transformation.
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References
Epstein, M. A. in Oncogenesis and Herpesviruses (eds Biggs, P. M. et al.) 261–274 (IARC Publs No. 2, 1972).
de-Thé, H. in Ontogenesis and Herpesviruses (eds Biggs, P. M. et al.) 275–284 (IARC Publs No. 2, 1972).
Nazerian, K. in Oncogenesis and Herpesviruses (eds Biggs, P. M. et al.) 59–73 (IARC Publs No. 2, 1972).
de-Thé, G. et al. Nature 274, 756–761 (1978).
Longenecker, B. M., Pazderka, F., Gavora, J. S., Spencer, J. S. & Ruth, R. F. Immunogenetics 3, 401–407 (1976).
Briles, W. E., Stone, H. A. & Cole, R. K. Science 195, 193–196 (1977).
Fredericksen, T. L., Longenecker, B. M., Pazderka, F., Gilmour, D. & Ruth, R. F. Immunogenetics 5, 535–552 (1977).
Powell, P. C., Payne, L. N., Frazier, J. A. & Rennie, M. in Oncogenesis and Herpesviruses II Part 2 (eds de-Thé, G. et al.) 89–100 (IARC Publs No. 11, 1975).
Longenecker, B. M., Pazderka, F., Stone, H. S., Gavora, J. S. & Ruth, R. F. Infect. Immun. 11, 922–931 (1975).
Gallatin, W. M. & Longenecker, B. M. Proc. EEC Symp. Resistance and Immunity to Marek's Disease, Berlin (in the press).
Sharma, J. M., Witter, R. L. & Purchase, H. G. Nature 253, 477–479 (1975).
Shieh, H. K. & Sevoian, M. Comparative Leukemia Research 1975 (eds Clemmsen, J. & Yohn, D. S.) 396–399 (Bibl. Haemat. No. 43, 1976).
Odaka, T. J. Virol. 3, 543–548 (1969).
Payne, L. N., Pani, P. K. & Weiss, R. A. J. gen. Virol. 13, 455–462 (1971).
Purchase, H. G., Gilmour, D. G., Romero, C. H. & Okazaki, W. Nature 270, 61–62 (1977).
Vogt, P. K. & Ishizaki, R. Virology 30, 664–672 (1965).
Pazderka, F., Longenecker, B. M., Law, G. R. J., Stone, H. A. & Ruth, R. F. Immunogenetics 2, 93–100 (1975).
Longenecker, B. M., Pazderka, F. & Ruth, R. F. J. Immunogenet. 2, 59–67 (1975).
Longenecker, B. M., Brietenbach, R. P. & Farmer, J. N. J. Immun. 97, 594–599 (1966).
Spencer, J. L., Gavora, J. S., Grunder, A. A., Robertson, A. & Speckman, G. A. Avian Dis. 18, 33–44 (1974).
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GALLATIN, W., LONGENECKER, B. Expression of genetic resistance to an oncogenic herpesvirus at the target cell level. Nature 280, 587–589 (1979). https://doi.org/10.1038/280587a0
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DOI: https://doi.org/10.1038/280587a0
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