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How does adrenaline accelerate the heart?

Abstract

THE way in which adrenaline acts on the sinoatrial (SA) node to accelerate the heart rate has hitherto been obscure. However, in various other parts of the heart adrenaline increases the slow inward (Ca2+/Na+) current1–4, and voltage-recording experiments have indicated that adrenaline also has this action in the sinus region5–7. In the voltage-clamp experiments reported here, we find that adrenaline does indeed increase the slow inward current in the SA node of the rabbit, but that it also augments the outward current which would tend to decelerate pacemaker depolarisation. We find that an additional current, if, is activated within the range of voltage where the pacemaker depolarisation occurs: this could be important both in normal pacemaking and in adrenaline-induced acceleration.

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References

  1. 1

    Hauswirth, O., Noble, D. & Tsien, R. W. Science 162, 916–917 (1968).

    ADS  CAS  Article  Google Scholar 

  2. 2

    Vassort, G. et al. Pflügers Arch. ges. Physiol. 309, 70–81 (1969).

    CAS  Article  Google Scholar 

  3. 3

    Brown, H. F. & Noble, S. J. J. Physiol., Lond. 238, 51–53P (1974).

    Article  Google Scholar 

  4. 4

    Reuter, H. & Scholz, H. J. Physiol., Lond. 264, 49–62 (1977).

    CAS  Article  Google Scholar 

  5. 5

    Kohlhardt, M., Figulla, H. R. & Tripathi, O. Basic Res. Cardiol. 71, 17–25 (1976).

    CAS  Article  Google Scholar 

  6. 6

    Brown, H. F., Giles, W. & Noble, S. J. in The Sinus Node (ed. Bonke, F. I. M.) (Martinus Nijhoff, The Hague, 1978).

    Google Scholar 

  7. 7

    Brown, H. F., DiFrancesco, D. & Noble, S. J. J. Physiol., Lond. 290, 31P–32P (1979).

    CAS  PubMed  Google Scholar 

  8. 8

    Noma, A., Yangihara, K. & Irisawa, I. Pflügers Arch. ges. Physiol. 372, 43–51 (1978).

    Article  Google Scholar 

  9. 9

    Noma, A., & Irisawa, I. Pflügers Arch. ges. Physiol. 364, 45–52 (1976).

    CAS  Article  Google Scholar 

  10. 10

    DiFrancesco, D., Noma, A. & Trautwein, W. Pflügers Arch. ges. Physiol. (in the press).

  11. 11

    Brown, H. F., DiFrancesco, D. & Noble, S. J. in Biological Oscillators (eds Berridge, M. J. & Rapp, P. E.) (Cambridge University Press, in the press).

  12. 12

    Brown, H. F., Giles, W. & Noble, S. J. J. Physiol., Lond. 271, 783–816 (1977).

    CAS  Article  Google Scholar 

  13. 13

    Noma, A. & Irisawa, I. Pflügers Arch. ges. Physiol. 366, 251–258 (1976).

    CAS  Article  Google Scholar 

Download references

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BROWN, H., DIFRANCESCO, D. & NOBLE, S. How does adrenaline accelerate the heart?. Nature 280, 235–236 (1979). https://doi.org/10.1038/280235a0

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