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Seminalplasmin—an antimicrobial protein from bovine seminal plasma which acts in E. coli by specific inhibition of rRNA synthesis


SEMINAL PLASMA—the fluid in which spermatozoa are ejaculated—has been known to inhibit reversibly both RNA and protein synthesis in sperm cells1–3. Here we report the isolation from seminal plasma, purification to homogeneity, and characterisation of a protein which we have called ‘seminalplasmin’, that specifically inhibits rRNA synthesis in Escherichia coli and is highly antimicrobial.

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REDDY, E., BHARGAVA, P. Seminalplasmin—an antimicrobial protein from bovine seminal plasma which acts in E. coli by specific inhibition of rRNA synthesis. Nature 279, 725–728 (1979).

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