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Biosynthesis of the major human red cell sialoglycoprotein, glycophorin A, in a continuous cell line

Nature volume 279, pages 604–607 (1979)Cite this article

Abstract

During biosynthesis of glycophorin A in K562 cells a precursor is rapidly transferred through the endoplasmic reticulum membrane with the COOH-terminal remaining in the cytoplasm. This is glycosylated within the cell and appears at the cell surface after about 30 min. The biosynthetic pathway resembles that described for viral membrane glycoproteins.

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Author information

Authors and Affiliations

  1. Department of Bacteriology and Immunology, University of Helsinki, Haartmaninkatu 3, SF 00290, Helsinki, 29, Finland

    Mikko Jokinen & Carl G. Gahmberg

  2. Transplantation Laborátory, and Department of Pathology, University of Helsinki,

    Leif C. Andersson

Authors
  1. Mikko Jokinen
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  2. Carl G. Gahmberg
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  3. Leif C. Andersson
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Jokinen, M., Gahmberg, C. & Andersson, L. Biosynthesis of the major human red cell sialoglycoprotein, glycophorin A, in a continuous cell line. Nature 279, 604–607 (1979). https://doi.org/10.1038/279604a0

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