Abstract
An analogue of epidermal growth factor (EGF) which is virtually devoid of biological activity retains receptor binding activity but cannot form cell surface clusters or patches. Bivalent anti-EGF antibodies restore both bioactivity and patch formation. The sensitivity of fibroblasts to native EGF can also be enhanced greatly by these antibodies, especially in hormone-resistant cell lines.
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Schechter, Y., Hernaez, L., Schlessinger, J. et al. Local aggregation of hormone–receptor complexes is required for activation by epidermal growth factor. Nature 278, 835–838 (1979). https://doi.org/10.1038/278835a0
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DOI: https://doi.org/10.1038/278835a0
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