Abstract
THE Abelson murine leukaemia virus (A-MuLV) complex, which consists of a replication-defective focus-forming virus and its helper Moloney leukaemia virus, causes a thymus-independent lymphosarcoma in BALB/c mice1. Infection in vivo leads to the production of tumours which are usually classified as ‘null’ lymphoid cells2, although immunoglobulin (Ig)-synthesising B-cell lines have been reported3–5 and macrophage lines may occasionally be produced6. In some cases, particularly with pretreatment of the mice with the mineral oil pristane, there is a high incidence of Ig-producing plasmacytomas7. Additional data on Ly phenotypes have suggested that most A-MuLV tumours, including those with no demonstrable Ig synthesis, may be B-cell lineage derivatives8. Here, we provide evidence for A-MuLV transformation of B-cell precursors resulting in two cell lines which retain the capacity for inducible IgM synthesis. Line ABC-1 was derived from BALB/c mouse bone marrow cells transformed in vitro by the Abelson virus9 and line ATV-3 from a tumour in a BALB/c mouse inoculated with A-MuLV.
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References
Abelson, H. T. & Rabstein, L. S. Cancer Res. 30, 2213–2222 (1970).
Pratt, D. M. et al. Cell 12, 683–690 (1977).
Rosenberg, N., Baltimore, D. & Scher, C. D. Proc. natn. Acad. Sci. U.S.A. 72, 1932–1936 (1975).
Premkumar, E., Potter, M., Singer, P. A. & Sklar, M. D. Cell 6, 149–159 (1975).
Weimann, B. J. Cold Spring Harb. Symp. quant. Biol. 41, 163–164 (1977).
Raschke, W. C., Baird, S., Ralph, P., & Nakoinz, I. Cell 15, 261–267 (1978).
Potter, M., Sklar, M. D. & Rowe, W. P. Science 182, 592–594 (1973).
Silverstone, A. E. et al. in Cold Spring Harb. Conf. Cell Proliferation Vol. 5 (eds Clarkson, B., Till, J. E. & Marks, P. A.) 432–452 (Cold Spring Harbor Press, New York, 1978).
Teich, N., Boss, M. & Dexter, T. M. in Modern Trends in Human Leukaemia Vol. 3 (eds Neth, R., Hofschneider, P-H. & Mannweiller, K.) (Springer, Berlin, in the press).
London, J. & Roelants, G. E. in 25th Colloq. Protides of the Biological Fluids (Pergamon Press, 1977).
Sutherland, D. R., Smart, J., Niaudet, P. & Greaves, M. F. Leukaemia Res. 2, 115–126 (1978).
Brown, G., Capellaro, D. & Greaves, M. F. J. natn. Cancer Inst. 55, 1281–1289 (1975).
Raff, M. C., Megson, M., Owen, J. J. T. & Cooper, M. D. Nature 259, 224–226 (1976).
Melchers, F., Andersson, J. & Phillips, R. A. Cold Spring Harb. Symp. quant. Biol. 41, 147–150 (1977).
Janossy, G. & Greaves, M. F. Transplantn Rev. 24, 177–236 (1975).
Ralph, P., Nakoinz, I. & Raschke, W. C. Biochem. biophys. Res. Commun. 61, 1268–1275 (1974).
Paige, C. J., Kincade, P. W. & Ralph, R. J. Immun. 121, 641–647 (1978).
Siden, E. J., Baltimore, D., Clark, D. & Rosenberg, N. Cell (in the press).
Rosenberg, N., Siden, E. & Baltimore, D. in B Lymphocytes and the Immune Response (eds Cooper, M., Mosier, D., Scher, I. & Vitetta, E.) (Eisevier, Amsterdam, in the press).
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Boss, M., GREAVES, M. & TEICH, N. Abelson virus-transformed haematopoietic cell lines with pre-B-cell characteristics. Nature 278, 551–553 (1979). https://doi.org/10.1038/278551a0
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DOI: https://doi.org/10.1038/278551a0
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