Premature termination during adenovirus transcription

Abstract

INITIATION of transcription, the first event in gene expression, is probably the most critical possible site for gene regulation. However, it has become clear from recent studies with bacteria and bacteriophages that a transcriptional start does not ensure the expression of a gene. For example, the phenomenon of ‘attenuation’, that is, premature termination of an mRNA chain before transcription of the structural gene region, is a key regulatory event for the synthesis of enzymes that make amino acids in bacteria1–4. We report here evidence for premature chain termination during transcription of an animal virus genome.

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EVANS, R., WEBER, J., ZIFF, E. et al. Premature termination during adenovirus transcription. Nature 278, 367–370 (1979). https://doi.org/10.1038/278367a0

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