Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Premature termination during adenovirus transcription

Nature volume 278, pages 367–370 (1979)Cite this article

Abstract

INITIATION of transcription, the first event in gene expression, is probably the most critical possible site for gene regulation. However, it has become clear from recent studies with bacteria and bacteriophages that a transcriptional start does not ensure the expression of a gene. For example, the phenomenon of ‘attenuation’, that is, premature termination of an mRNA chain before transcription of the structural gene region, is a key regulatory event for the synthesis of enzymes that make amino acids in bacteria1–4. We report here evidence for premature chain termination during transcription of an animal virus genome.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Betrand, K. et al. Science 189, 22–36 (1975).

    Article  ADS  Google Scholar 

  2. Artz, S. & Broach, J. Proc. natn. Acad, Sci. U.S.A. 72, 3452–3457 (1975).

    Article  ADS  Google Scholar 

  3. Zurawski, G., Brown, K., Killingly, D. & Yanofsky, C. Proc. natn. Acad. sci. U.S.A. 75, 4271–4275 (1978).

    Article  ADS  CAS  Google Scholar 

  4. Barnes, W. Proc. natn. Acad. Sci. U.S.A. 75, 4281–4285 (1978).

    Article  ADS  CAS  Google Scholar 

  5. Flint, J. Cell 10, 153–166 (1977).

    Article  CAS  PubMed  Google Scholar 

  6. Chow, L. T., Roberts, J.-M., Lewis, J. B. & Broker, T. R. Cell 11, 919–936 (1977).

    Article  Google Scholar 

  7. Nevins, J. R. & Darnell, J. E. J. Virol. 25, 811–823 (1978).

    CAS  PubMed  PubMed Central  Google Scholar 

  8. Weber, J., Jelinek, W. & Darnell, J. E. Cell 10, 612–617 (1977).

    Google Scholar 

  9. Evans, R. et al. Cell 12, 733–739 (1977).

    Article  CAS  PubMed  Google Scholar 

  10. Goldberg, S., Nevins, J. R. & Darnell, J. E. J. Virol. 25, 806–810 (1978).

    CAS  PubMed  PubMed Central  Google Scholar 

  11. Chow, L. T., Gelinas, R. E., Broker, T. R. & Roberts, R. J. Cell 12, 1–8 (1977).

    Article  CAS  PubMed  Google Scholar 

  12. Klessig, D. Cell 12, 9–21 (1977).

    Article  CAS  PubMed  Google Scholar 

  13. Berget, S., Moore, C. & Sharp, P. A. Proc. natn. Acad. Sci. U.S.A. 74, 3171–3175 (1977).

    Article  ADS  CAS  Google Scholar 

  14. Nevins, J. R. & Darnell, J. E. Cell 15, 1477–1493 (1978).

    Article  CAS  PubMed  Google Scholar 

  15. Ziff, E. & Evans, R. Cell 15, 1463–1475 (1978).

    Article  CAS  PubMed  Google Scholar 

  16. Bachenheimer, S. & Darnell, J. E. Proc. natn. Acad. Sci. U.S.A. 72, 4445–4449 (1975).

    Article  ADS  CAS  Google Scholar 

  17. Derman, E., Goldberg, S. & Darnell, J. R. Cell 9, 465–472 (1976).

    Article  CAS  PubMed  Google Scholar 

  18. Goldberg, S., Weber, J. & Darnell, J. E. Cell 10, 617–623 (1977).

    Article  CAS  PubMed  Google Scholar 

  19. Fraser, N., Nevins, J. R., Ziff, E. & Darnell, J. E. J. molec. Biol. (in the press).

  20. Wilson, M., Fraser, N. W. & Darnell, J. E. Virology (in the press).

  21. Fraser, N., Sehgal, P. B. & Darnell, J. E. Nature 274, 590–593 (1978).

    Article  ADS  Google Scholar 

  22. Sehgal, P. B., Fraser, N. W. & Darnell, J. E. Virology (in the press).

  23. Roeder, R. G. & Rutter, W. J. Proc. natn. Acad. Sci. U.S.A. 65, 675–682 (1970).

    Article  ADS  CAS  Google Scholar 

  24. Roberts, J. Nature 224, 1168–1174 (1969).

    Article  ADS  CAS  PubMed  Google Scholar 

  25. Roberts, J. Proc. natn. Acad. Sci. U.S.A. 72, 3300–3304 (1975).

    Article  ADS  CAS  Google Scholar 

  26. Tamm, I. Proc. natn. Acad. Sci. U.S.A. 74, 5011–5015 (1977).

    Article  ADS  CAS  Google Scholar 

  27. Wall, R. & Darnell, J. R. Nature new Biol. 232, 73–76 (1971).

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. The Rockefeller University, New York, New York, 10021

    R. EVANS, J. WEBER, E. ZIFF & J. E. DARNELL

Authors
  1. R. EVANS
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. J. WEBER
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. E. ZIFF
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. J. E. DARNELL
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

EVANS, R., WEBER, J., ZIFF, E. et al. Premature termination during adenovirus transcription. Nature 278, 367–370 (1979). https://doi.org/10.1038/278367a0

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/278367a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing