Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Article
  • Published:

The chick ovomucoid gene contains at least six intervening sequences

Abstract

A 15-kilobase pair EcoRI chick DNA fragment, containing both the termination codon UGA and the 5′-portion of the structural ovomucoid gene, has been cloned in λ phage Charon 4A by in vitro packaging. Restriction mapping and electron microscopic analyses of this cloned DNA have revealed that the structural ovomucoid gene sequences are separated by at least six intervening sequences.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. O'Malley, B. W., McGuire, W. L., Kohler, P. O. & Korenman, S. G. Recent Prog. Horm. Res. 25, 150–160 (1969).

    Google Scholar 

  2. Oka, T. & Schimke, R. T. J. Cell Biol. 43, 123–137 (1969).

    Article  CAS  PubMed Central  Google Scholar 

  3. Palmiter, R. D. J. biol. Chem. 247, 6450–6461 (1972).

    CAS  PubMed  Google Scholar 

  4. Hynes, N. E., Groner, B., Sippel, A. E., Nguyen-Huu, M. C. & Schutz, G. Cell 11, 923–932 (1978).

    Article  Google Scholar 

  5. Stein, J. P., Catterall, J. F., Woo, S. L. C., Means, A. R. & O'Malley, B. W. Biochemistry 17, 5763–5772 (1978).

    Article  CAS  Google Scholar 

  6. Tsai, S. Y. et al. Biochemistry 17, 5773–5780 (1978).

    Article  CAS  Google Scholar 

  7. Harris, S. E., Rosen, J. M., Means, A. R. & O'Malley, B. W. Biochemistry 14, 2072–2081 (1975).

    Article  CAS  Google Scholar 

  8. Monahan, J. J., Harris, S. E. & O'Malley, B. W. J. biol. Chem. 251, 3738–3748 (1976).

    CAS  PubMed  Google Scholar 

  9. Rhoads, R. E., McKnight, G. S. & Schimke, R. T. J. biol. Chem. 248, 2031–2039 (1973).

    CAS  PubMed  Google Scholar 

  10. Woo, S. L. C. et al. Proc. natn. Acad. Sci. U.S.A. 75, 3688–3692 (1978).

    Article  ADS  CAS  Google Scholar 

  11. Dugaiczyk, A. et al. Nature 274, 328–333 (1978).

    Article  ADS  CAS  PubMed Central  Google Scholar 

  12. Garapin, A. C. et al. Nature 273, 349–354 (1978).

    Article  ADS  CAS  Google Scholar 

  13. Garapin, A. C. et al. Cell 14, 629–639 (1978).

    Article  CAS  PubMed Central  Google Scholar 

  14. Mandel, J. L. et al. Cell 14, 641–653 (1978).

    Article  CAS  PubMed Central  Google Scholar 

  15. Maniatis, T., Jeffrey, A. & Kleid, D. G. Proc. natn. Acad. Sci. U.S.A. 72, 1184–1189 (1975).

    Article  ADS  CAS  Google Scholar 

  16. Southern, E. M. J. molec. Biol. 98, 503–518 (1975).

    Article  CAS  PubMed Central  Google Scholar 

  17. Denhardt, D. Biochem. biophys. Res. Commun. 23, 641–646 (1966).

    Article  CAS  PubMed Central  Google Scholar 

  18. Laskey, R. A. & Mills, A. D. FEBS Lett. 82, 314–316 (1977).

    Article  CAS  PubMed Central  Google Scholar 

  19. Sternberg, N., Tiemeier, D. & Enquist, L. Gene 1, 255–280 (1977).

    Article  CAS  PubMed Central  Google Scholar 

  20. Nordstrom, J. L., Roop, D. R., Tsai, M.-J. & O'Malley, B. W. Nature 278, 328–331 (1979).

    Article  ADS  CAS  PubMed Central  Google Scholar 

  21. Weinstock, R., Sweet, R., Weiss, M., Cedar, H. & Axel, R. Proc. natn. Acad. Sci. U.S.A. 75, 1299–1303 (1978).

    Article  ADS  CAS  Google Scholar 

  22. Tilghman, S. M. et al. Proc. natn. Acad. Sci. U.S.A. 74, 4406–4410 (1977).

    Article  ADS  CAS  Google Scholar 

  23. Tiemeier, D. et al. Cell 14, 236–245 (1978).

    Article  Google Scholar 

  24. Maniatis, T. et al. Cell 15, 687–701 (1978).

    Article  CAS  PubMed Central  Google Scholar 

  25. Tonegawa, S., Brack, C., Hozumi, N. & Schuller, R. Proc. natn. Acad. Sci. U.S.A. 74, 3518–3522 (1977).

    Article  ADS  CAS  Google Scholar 

  26. Brack, C. & Tonegawa, Proc. natn. Acad. Sci. U.S.A. 74, 5652–5656 (1977).

    Article  ADS  CAS  Google Scholar 

  27. Tonegawa, S., Maxam, A. M., Tizard, R., Bernard, O. & Gilbert, W. Proc. natn. Acad. Sci. U.S.A. 75, 1485–1489 (1978).

    Article  ADS  CAS  Google Scholar 

  28. Seidman, J. G. et al. Proc. natn. Acad. Sci. U.S.A. 75, 3881–3885 (1978).

    Article  ADS  CAS  Google Scholar 

  29. Seidman, J. G., Edgell, M. H. & Leder, P. Nature 271, 582–585 (1978).

    Article  ADS  CAS  Google Scholar 

  30. Roop, D. R., Nordstrom, J. L., Tsai, S. Y., Tsai, M.-J. & O'Malley, B. W. Cell 15, 671–685 (1978).

    Article  CAS  PubMed Central  Google Scholar 

  31. Tilghman, S. M., Curtis, P. J., Tiemeier, D. C., Leder, P. & Weissman, C. Proc. natn. Acad. Sci. U.S.A. 75, 1309–1313 (1978).

    Article  ADS  CAS  Google Scholar 

  32. Chow, L. T., Gelinas, R. E., Broker, T. R. & Roberts, R. J. Cell 12, 1–8 (1977).

    Article  CAS  Google Scholar 

  33. Berk, A. J. & Sharp, P. A. Proc. natn. Acad. Sci. U.S.A. 75, 1274–1278 (1978).

    Article  ADS  CAS  Google Scholar 

  34. Knapp, G., Beckmann, J. S., Johnson, P. F., Fuhrman, S. A. & Abelson, J. Cell 14, 221–236 (1978).

    Article  CAS  Google Scholar 

  35. O'Farrell, P. Z., Cordell, B., Valenzuela, P., Rutter, W. J. & Goodman, H. M. Nature 274, 438–445 (1978).

    Article  ADS  CAS  PubMed Central  Google Scholar 

  36. Lai, E. C., Woo, S. L. C., Dugaiczyk, A. & O'Malley, B. W. Cell (in the press).

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Catterall, J., Stein, J., Lai, E. et al. The chick ovomucoid gene contains at least six intervening sequences. Nature 278, 323–327 (1979). https://doi.org/10.1038/278323a0

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/278323a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing