Abstract
How does a trimeric G protein on the inside of a cell membrane respond to activation by a transmembrane receptor? G-protein mutations in patients with hypertension and inherited endocrine disorders enhance or block signals from stimulated receptors. In combination with three-dimensional crystal structures and results from biochemical experiments, the phenotypes produced by these mutations suggest a model for the molecular activation mechanism that relays hormonal and sensory signals transmitted by many transmembrane receptors.
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Acknowledgements
This work was supported in part by a Julius Comroe Fellowship (T.I.), grants from the United States–Israel Binational Foundation and the Israeli Ministry of Health (Z.F.), and by NIH grants (H.R.B.).
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Iiri, T., Farfel, Z. & Bourne, H. G-protein diseases furnish a model for the turn-on switch. Nature 394, 35–38 (1998). https://doi.org/10.1038/27831
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DOI: https://doi.org/10.1038/27831
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