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T antigen is bound to a host protein in SY40-transformed cells

Abstract

THE early region of the small DNA tumour virus, simian virus 40 (SV40), is known to code for at least two polypeptides, the t and T antigens (‘small t’ and ‘large T’). Both these polypeptides are expressed in cells transformed by the virus1–4, and the T antigen has been shown to be essential for both the initiation and maintenance of the transformed state5–9. We therefore need to know how this T protein interacts with components of the host cell in order to understand the mechanism of SV40-induced transformation. We report here that the T antigen in a line of SV40-transformed mouse cells forms an oligomeric complex with a specific cell coded protein.

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References

  1. 1

    Prives, C., Gilboa, A. & Revel, M. Proc. natn. Acad. Sci. U.S.A. 74, 457–461 (1977).

    ADS  CAS  Article  Google Scholar 

  2. 2

    Crawford, L. V. et al. Proc. natn. Acad. Sci. U.S.A. 75, 117–121 (1978).

    ADS  CAS  Article  Google Scholar 

  3. 3

    Sleigh, M. J., Topp, W. C., Hanich, R. & Sambrook, J. Cell 14, 79–88 (1978).

    CAS  Article  Google Scholar 

  4. 4

    Paucha, E. et al. Proc. natn. Acad. Sci. U.S.A. 75, 2165–2169 (1978).

    ADS  CAS  Article  Google Scholar 

  5. 5

    Martin, R. C. & Chou, J. Y. J. Virol. 15, 599–612 (1975).

    CAS  PubMed  PubMed Central  Google Scholar 

  6. 6

    Tegtmeyer, P., Schwartz, M., Collins, J. K. & Rundell, K. J. Virol. 16, 168–178 (1975).

    CAS  PubMed  PubMed Central  Google Scholar 

  7. 7

    Brugge, J. S. & Butel, J. S. J. Virol. 15, 619–635 (1975).

    CAS  PubMed  PubMed Central  Google Scholar 

  8. 8

    Kimura, G. & Itagaki, A. Proc. natn. Acad. Sci. U.S.A. 72, 673–677 (1975).

    ADS  CAS  Article  Google Scholar 

  9. 9

    Brockman, W. W. J. Virol. 25, 860–870 (1978).

    CAS  PubMed  PubMed Central  Google Scholar 

  10. 10

    Lane, D. P. & Robbins, A. K. Virology 87, 182–193 (1978).

    CAS  Article  Google Scholar 

  11. 11

    Paucha, E., Harvey, R., Smith, R. & Smith, A. E. INSERM Colloq. 69, 189–198 (1977).

    CAS  Google Scholar 

  12. 12

    Cicurel, L. & Croce, C. M. J. Immun. 119, 850–854 (1977).

    CAS  PubMed  Google Scholar 

  13. 13

    Lewis, A. M. & Rowe, W. P. J. Virol. 7, 189–197 (1971).

    CAS  PubMed  PubMed Central  Google Scholar 

  14. 14

    Robb, J. A. Proc. natn. Acad. Sci. U.S.A. 74, 447–451 (1977).

    ADS  CAS  Article  Google Scholar 

  15. 15

    Grey, H. M. et al. J. exp. Med. 138, 1608–1612 (1973).

    CAS  Article  Google Scholar 

  16. 16

    Fiers, W. et al. Nature 273, 113–120 (1978).

    ADS  CAS  Article  Google Scholar 

  17. 17

    Reddy, V. B. et al. Science 200, 494–502 (1978).

    ADS  CAS  Article  Google Scholar 

  18. 18

    Berk, A. J. & Sharp, P. A. Proc. natn. Acad. Sci. U.S.A. 75, 1274–1278 (1978).

    ADS  CAS  Article  Google Scholar 

  19. 19

    Tegtmeyer, P. J. Virol. 10, 591–598 (1972).

    CAS  PubMed  PubMed Central  Google Scholar 

  20. 20

    Kessler, S. W. J. Immun. 115, 1617–1624 (1975).

    CAS  Google Scholar 

  21. 21

    Ward, S., Wilson, D. L. & Gilliam, J. J. Analyt. Biochem. 38, 90–97 (1970).

    CAS  Article  Google Scholar 

  22. 22

    Carroll, R. B., Goldfine, F. M. & Melero, J. A. Virology 87, 194–198 (1978).

    CAS  Article  Google Scholar 

  23. 23

    Gaudry, P., Rassoulzadegan, M. & Cuzin, F. Proc. natn. Acad. Sci. U.S.A. 75, 4987–4991 (1978).

    ADS  Article  Google Scholar 

  24. 24

    Edwards, C. A. F., Khoury, G. & Martin, R. G. J. Virol. 29, 753–762 (1979).

    CAS  PubMed  PubMed Central  Google Scholar 

  25. 25

    Chang, C., Simmons, D. T., Martin, M. A. & Mora, P. T. J. Virol. (submitted).

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LANE, D., CRAWFORD, L. T antigen is bound to a host protein in SY40-transformed cells. Nature 278, 261–263 (1979). https://doi.org/10.1038/278261a0

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