Substance P inhibits nicotinic activation of chromaffin cells

Abstract

THERE is much interest in the possibility that substance P acts as a neurotransmitter and/or a neuromodulator at certain sites in the central and peripheral nervous system (for reviews see refs 1, 2). Although both excitatory3–8 and inhibitory6,9–11 actions have been observed in vivo and in vitro, the cellular mechanism of action of substance P has not been defined. Recent electrophysiological studies in the cat9–11 have provided evidence that substance P selectively depresses the nicotinic excitation of Renshaw cells by microiontophoretic application of acetylcholine (ACh). We show here that substance P inhibits the ACh-induced nicotinic response of adrenal chromaffin cells in culture to release 3H-noradrenaline.

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LIVETT, B., KOZOUSEK, V., MIZOBE, F. et al. Substance P inhibits nicotinic activation of chromaffin cells. Nature 278, 256–257 (1979). https://doi.org/10.1038/278256a0

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