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Dopamine inhibits adenylate cyclase in human prolactin-secreting pituitary adenomas

Nature volume 278, pages 252–254 (1979)Cite this article

Abstract

THERE is evidence for the existence of multiple forms of dopamine (DA) receptors1–3. In particular, some of these receptors are coupled to adenylate cyclase (DA-stimulating enzyme activity), whereas others seem to be independent3–5. These two classes of receptors, which have been designated D-1 and D-2, respectively, would also have different pharmacological properties3. Pituitary mammotroph DA receptors regulating prolactin (PRL) secretion are considered to be typical D-2 receptors. A DA-stimulated adenylate cyclase has not been detected in normal anterior pituitaries3,5,6; furthermore, several studies indicate that cyclic AMP is stimulatory and not inhibitory to PRL secretion7,8. We report here that in homogenates of human PRL adenomas, in which dopaminergic agonists act as inhibitors of PRL secretion, basal adenylate cyclase is inhibited by DA. The DA receptors mediating this inhibition have the same pharmacological properties as those regulating PRL secretion.

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Author notes

  1. PIETRO DE CAMILLI

    Present address: Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut, 06510

Authors and Affiliations

  1. CNR Center of Cytopharmacology and Department of Pharmacology, University of Milan, Italy

    PIETRO DE CAMILLI & DANIELA MACCONI

  2. Endocrine Unit, II Medical Clinic, University of Milan, Italy

    ANNA SPADA

Authors
  1. PIETRO DE CAMILLI
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  2. DANIELA MACCONI
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  3. ANNA SPADA
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DE CAMILLI, P., MACCONI, D. & SPADA, A. Dopamine inhibits adenylate cyclase in human prolactin-secreting pituitary adenomas. Nature 278, 252–254 (1979). https://doi.org/10.1038/278252a0

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