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HLA and testicular cancer

Naturevolume 277pages216217 (1979) | Download Citation



HLA IS involved not only in transplantation, but is also associated with many disease states. This first became evident when the major histocompatibility complex of the mouse (H–2) was shown to play a major part in determining resistance to Gross leukaemia virus1. Subsequent studies in both animals and man have shown that many disease states are associated with, and perhaps regulated by, the major histocompatibility complex2,3. We now present the tissue typing results from a group of patients with testicular cancer. The results show an abnormally high antigen frequency for HLA-Dw7 in patients with testicular teratocarcinoma.

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  1. 1

    Lilly, F., Boyse, E. A. & Old, L. J. Lancet ii, 1207–1209 (1964).

  2. 2

    Dausset, J. & Svejgaard, A. (eds) HLA and Disease (Munksgaard, Copenhagen, 1977).

  3. 3

    McDevitt, H. O. & Bodmer, W. F. Lancet i, 1269–1275 (1974).

  4. 4

    O'Leary, J., Reinsmoen, N. & Yunis, E. J. in Manual of Clinical Immunology (eds Rose, N. & Friedman, H.) 821–832 (Am. Soc. Microbiol., Washington, 1976).

  5. 5

    Cannady, W. G., DeWolf, W. C., Williams, R. M. & Yunis, E. J. Prog. clin. Pathol. 7, 239–265 (1978).

  6. 6

    Svejgaard, A. in Manual of Clinical Immunology (eds Rose, N. & Friedman, H.) 841–850 (Am. Soc. Microbiol., Washington, 1976).

  7. 7

    Miller, L. H., Mason, S. J., Dvorak, J. A., McGinniss, M. H. & Rothman, I. K. Science 189, 561–563 (1975).

  8. 8

    Ochs, H. D. et al. New Engl. J. Med. 296, 470–475 (1977).

  9. 9

    Lapes, M. Iozzi, L., Ziegenfus, W., Antoniades, K. & Vivagua, R. Cancer 39, 2317–2320 (1977).

  10. 10

    Artzt, K. & Bennett, D. Nature 256, 545–547 (1975).

  11. 11

    Klein, J. & Hammerberg, C. Immun. Rev. 33, 70–104 (1977).

  12. 12

    Bennett, D. Cell 6, 441–454 (1975).

  13. 13

    Jacob, F. Immun. Rev. 33, 3–32 (1977).

  14. 14

    Artzt, K., Bennett, D., Boyse, E. A. & Jacob, F. Proc. natn. Acad. Sci. U.S.A. 70, 2988–2993 (1973).

  15. 15

    Vitetta, E., Artzt, K., Bennett, D., Boyse, E. A. & Jacob, G. Proc. natn. Acad. Sci. U.S.A. 72, 3215–3219 (1975).

  16. 16

    Amos, D. B., Johnson, A. H., Ruderman, R. J., Mendell, N. & Yunis, E. J. New Concepts in Transplantation Immunity (ed., Canley, R.) (M. D. Anderson Symposium, University of Texas, Houston, 1975).

  17. 17

    Buc-Caron, M., Gachelin, G., Hofnung, M. & Jacob, F. Proc. natn. Acad. Sci. U.S.A. 71, 1730–1734 (1974).

  18. 18

    Hogan, B., Fellous, M., Avner, P. & Jacob, F. Nature 270, 515–517 (1977).

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  1. Sidney Farber Cancer Institute, Harvard Medical School, and The Northeast Regional Red Cross Blood Program, Boston, Massachusetts, 02115

    •  & EDMOND J. YUNIS
  2. Department of Urologic Surgery, University of Minnesota, Minneapolis, Minnesota



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