Letter | Published:

Inactivation of restriction endonuclease BamNx after infection with phage φNR2

Naturevolume 277pages6466 (1979) | Download Citation

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Abstract

A HOST-CONTROLLED restriction–modification system1–3 is a means of protection by a host against attacks of bacteriophages. Recently, coliphage T3 and T7 have been found to overcome4–7 the host-controlled restriction–modification systems of their host strains Escherichia coli B and K, but details of the mechanism are not well understood at present. We have found that a Bacillus subtilis phage φNR2rH, a mutant of φNR2 (ref. 8), also has the ability to overcome the restriction–modification system of B. amyloliquefaciens strain N, and detected a BamNx inhibitor in cells infected with φNR2rH.

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References

  1. 1

    Arber, W. Progr. nucl. Acid Res. molec. Biol. 14, (ed. Cohen W. E.) 1–37 (Academic, New York 1974).

  2. 2

    Boyer, H. W. A. Rev. Microbiol. 25, 153–176 (1971).

  3. 3

    Roberts, R. J. CRC Crit. Rev. Biochem. 123–164 (November 1976).

  4. 4

    Eskin, B., Lautenberger, J. A. & Linn, S. J. Virol. 11, 1020–1023 (1973).

  5. 5

    Studier, F. W. J. molec. Biol. 94, 283–295 (1975).

  6. 6

    Studier, F. W. & Movva, N. R. J. Virol. 19, 136–145 (1976).

  7. 7

    Krüger, D. H., Schroeder, C., Hansen, S. & Rosenthal, H. A. Molec. gen. Genet. 153, 99–106 (1977).

  8. 8

    Yajima, Y., Saito, H. & Ikeda, Y. J. gen. appl. Microbiol. (in the press).

  9. 9

    Shibata, T. & Ando, T. Molec. gen. Genet. 131, 275–280 (1974).

  10. 10

    Shibata, T. & Ando, T. ibid. 138, 269–279 (1975).

  11. 11

    Shibata, T. & Ando, T. Biochim. biophys. Acta 442, 184–196 (1976).

  12. 12

    Wilson, G. A. & Young, F. E. J. molec. Biol. 97, 123–125 (1975).

  13. 13

    Roberts, R. J., Wilson, G. A. & Young, F. E. Nature 265, 82–84 (1977).

  14. 14

    Yajima, Y., Saito, H. & Ikeda, Y. J. gen. appl. Microbiol. (in the press).

  15. 15

    Löening, U. E. J. molec. Biol. 38, 355–365 (1968).

  16. 16

    Aaji, C. & Borst, P. Biochim. biophys. Acta 269, 192–200 (1972).

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Affiliations

  1. The Institute of Applied Microbiology, The University of Tokyo, Bunkyo-ku, Tokyo, Japan

    • OSAMU MAKINO
    • , FUJIO KAWAMURA
    • , HIUGA SAITO
    •  & YONOSUKE IKEDA

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https://doi.org/10.1038/277064a0

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