Abstract
A HOST-CONTROLLED restriction–modification system1–3 is a means of protection by a host against attacks of bacteriophages. Recently, coliphage T3 and T7 have been found to overcome4–7 the host-controlled restriction–modification systems of their host strains Escherichia coli B and K, but details of the mechanism are not well understood at present. We have found that a Bacillus subtilis phage φNR2rH, a mutant of φNR2 (ref. 8), also has the ability to overcome the restriction–modification system of B. amyloliquefaciens strain N, and detected a BamNx inhibitor in cells infected with φNR2rH.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Arber, W. Progr. nucl. Acid Res. molec. Biol. 14, (ed. Cohen W. E.) 1–37 (Academic, New York 1974).
Boyer, H. W. A. Rev. Microbiol. 25, 153–176 (1971).
Roberts, R. J. CRC Crit. Rev. Biochem. 123–164 (November 1976).
Eskin, B., Lautenberger, J. A. & Linn, S. J. Virol. 11, 1020–1023 (1973).
Studier, F. W. J. molec. Biol. 94, 283–295 (1975).
Studier, F. W. & Movva, N. R. J. Virol. 19, 136–145 (1976).
Krüger, D. H., Schroeder, C., Hansen, S. & Rosenthal, H. A. Molec. gen. Genet. 153, 99–106 (1977).
Yajima, Y., Saito, H. & Ikeda, Y. J. gen. appl. Microbiol. (in the press).
Shibata, T. & Ando, T. Molec. gen. Genet. 131, 275–280 (1974).
Shibata, T. & Ando, T. ibid. 138, 269–279 (1975).
Shibata, T. & Ando, T. Biochim. biophys. Acta 442, 184–196 (1976).
Wilson, G. A. & Young, F. E. J. molec. Biol. 97, 123–125 (1975).
Roberts, R. J., Wilson, G. A. & Young, F. E. Nature 265, 82–84 (1977).
Yajima, Y., Saito, H. & Ikeda, Y. J. gen. appl. Microbiol. (in the press).
Löening, U. E. J. molec. Biol. 38, 355–365 (1968).
Aaji, C. & Borst, P. Biochim. biophys. Acta 269, 192–200 (1972).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
MAKINO, O., KAWAMURA, F., SAITO, H. et al. Inactivation of restriction endonuclease BamNx after infection with phage φNR2. Nature 277, 64–66 (1979). https://doi.org/10.1038/277064a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/277064a0
This article is cited by
-
Restriction and modification in Bacillus subtilis: Identification of a gene in the temperate phage SPβ coding for a BsuR specific modification methyltransferase
Molecular and General Genetics MGG (1980)
-
Transformation and transduction of Bacillus subtilis strains with the Bsu R restriction-modification system by means of modified and unmodified DNA of pUB110 plasmid
Molecular and General Genetics MGG (1980)
-
Bacillus subtilis-phage φ1 overcomes host-controlled restriction by producing BamNx inhibitor protein
Molecular and General Genetics MGG (1980)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
