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Re-evaluation of the number of specific β-adrenergic receptors on muscle cells

Abstract

IT has been reported by Atlas, Hanski and Levitzki that muscle cells have an unusually high number of β adrenoreceptors, 80,000 per cell1 However, we consider the pharmacological characterisation of these receptors as specific β adrenoreceptors unsatisfactory. We report here that the number of specific β adrenoreceptors in a similar but not identical muscle cell line of the same origin is 8,000 rather than their stated figure of 80,000, and is therefore comparable to that found on C6 glioma cells.

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References

  1. Atlas, D., Hanski, E. & Levitzki, A. Nature 268, 144–146 (1977).

    Article  ADS  CAS  Google Scholar 

  2. Schmitt, H. & Pochet, R. FEBS Lett. 76, 302–305 (1977).

    Article  CAS  Google Scholar 

  3. Sporn, J. R. & Molinoff, P. B. J. Cyclic Nudeotides Res. 2, 149–161 (1976).

    CAS  Google Scholar 

  4. Maguire, M. E., Wiklund, R. A., Anderson, H. J. & Gilman, A. G. J. biol. Chem. 250, 1221–1231 (1976).

    Google Scholar 

  5. Lucas, M. & Bockaert, J. molec. Pharmac. 13, 314–329 (1977).

    CAS  Google Scholar 

  6. Yaffe, D. Proc. natn. Acad. Sci. U.S.A. 61, 477–481 (1968).

    Article  ADS  CAS  Google Scholar 

  7. Brown, E. M., Aurbach, C. D., Hauser, D. & Troxler, F. J. biol. Chem. 251, 1232–1238 (1976).

    CAS  PubMed  Google Scholar 

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POCHET, R., SCHMITT, H. Re-evaluation of the number of specific β-adrenergic receptors on muscle cells. Nature 277, 58–59 (1979). https://doi.org/10.1038/277058a0

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  • DOI: https://doi.org/10.1038/277058a0

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